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    ALS2 alsin Rho guanine nucleotide exchange factor ALS2 [ Gallus gallus (chicken) ]

    Gene ID: 424085, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ALS2provided by CGNC
    Official Full Name
    alsin Rho guanine nucleotide exchange factor ALS2provided by CGNC
    Primary source
    CGNC:6377
    See related
    Ensembl:ENSGALG00010025055
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (11163034..11379405, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (11084044..11300104, complement)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 237 Neighboring gene membrane palmitoylated protein 4 Neighboring gene cyclin dependent kinase 15 Neighboring gene frizzled class receptor 7 Neighboring gene uncharacterized LOC101747813 Neighboring gene small nucleolar RNA SNORD70 Neighboring gene small ubiquitin-like modifier 1 Neighboring gene NOP58 ribonucleoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alsin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      11163034..11379405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046943915.1 → XP_046799871.1  alsin isoform X1

      UniProtKB/TrEMBL
      A0A8V1A5Z0

    2. XM_015289451.4 → XP_015144937.2  alsin isoform X1

      UniProtKB/TrEMBL
      A0A8V1A5Z0
      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    3. XM_046943916.1 → XP_046799872.1  alsin isoform X2

    4. XM_040703897.2 → XP_040559831.1  alsin isoform X1

      UniProtKB/TrEMBL
      A0A8V1A5Z0
      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    5. XM_046943917.1 → XP_046799873.1  alsin isoform X2

    6. XM_421940.8 → XP_421940.3  alsin isoform X1

      UniProtKB/TrEMBL
      A0A8V1A5Z0
      Related
      ENSGALP00010037846.1, ENSGALT00010061174.1
      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    7. XM_015289455.4 → XP_015144941.2  alsin isoform X2

      Conserved Domains (6) summary
      PLN03185
      Location:927 → 1045
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1051 → 1151
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:366 → 519
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:784 → 889
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1433 → 1532
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:574 → 761
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    8. XM_004942617.5 → XP_004942674.2  alsin isoform X1

      UniProtKB/TrEMBL
      A0A8V1A5Z0
      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    9. XM_046943918.1 → XP_046799874.1  alsin isoform X2

    10. XM_015289452.4 → XP_015144938.2  alsin isoform X1

      UniProtKB/TrEMBL
      A0A8V1A5Z0
      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    11. XM_004942618.5 → XP_004942675.2  alsin isoform X1

      UniProtKB/TrEMBL
      A0A8V1A5Z0
      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    RNA

    1. XR_001467427.4 RNA Sequence

    2. XR_001467425.4 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      11084044..11300104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046922013.1 → XP_046777969.1  alsin isoform X1

    2. XM_040676148.2 → XP_040532082.1  alsin isoform X1

      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    3. XM_046922014.1 → XP_046777970.1  alsin isoform X2

    4. XM_040676149.2 → XP_040532083.1  alsin isoform X1

      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    5. XM_046922015.1 → XP_046777971.1  alsin isoform X2

    6. XM_040676146.2 → XP_040532080.1  alsin isoform X1

      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    7. XM_040676150.2 → XP_040532084.1  alsin isoform X2

      Conserved Domains (6) summary
      PLN03185
      Location:927 → 1045
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1051 → 1151
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:366 → 519
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:784 → 889
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1433 → 1532
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:574 → 761
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    8. XM_040676144.2 → XP_040532078.1  alsin isoform X1

      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    9. XM_046922016.1 → XP_046777972.1  alsin isoform X2

    10. XM_040676145.2 → XP_040532079.1  alsin isoform X1

      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    11. XM_040676147.2 → XP_040532081.1  alsin isoform X1

      Conserved Domains (6) summary
      PLN03185
      Location:1040 → 1158
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:1164 → 1264
      COG4642; Uncharacterized conserved protein [Function unknown]
      COG5184
      Location:13 → 216
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13269
      Location:897 → 1002
      PH_alsin; Alsin Pleckstrin homology (PH) domain
      pfam02204
      Location:1546 → 1645
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl02571
      Location:687 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    RNA

    1. XR_005851718.2 RNA Sequence

    2. XR_005851717.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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