U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Smug Single-strand-selective monofunctional uracil-DNA glycosylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42078, updated on 4-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Smugprovided by FlyBase
    Official Full Name
    Single-strand-selective monofunctional uracil-DNA glycosylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038490
    Locus tag
    Dmel_CG5285
    See related
    AllianceGenome:FB:FBgn0038490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5285; CG5285_Dm_7300236; Dmel\CG5285; dmSMUG1; SMUG; SMUG1; ssUDG
    Summary
    Predicted to enable oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity and uracil DNA N-glycosylase activity. Predicted to be involved in base-excision repair. Orthologous to human SMUG1 (single-strand-selective monofunctional uracil-DNA glycosylase 1). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    89F1-89F1; 3-60 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17150587..17151630)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12976309..12977352)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mann-cup Neighboring gene uncharacterized protein Neighboring gene Deterin Neighboring gene Mucin related 89F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A DNA glycosylase for oxidized thymine residues in Drosophila melanogaster. Breimer LH. Biochem Biophys Res Commun, 1986 Jan 14. PMID 3004428
    2. Uracil-DNA glycosylase in insects. Drosophila and the locust. Morgan AR, et al. J Biol Chem, 1989 Jun 15. PMID 2722884
    3. The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs. Hardeland U, et al. Nucleic Acids Res, 2003 May 1. PMID 12711670, Free PMC Article
    4. Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals. Merényi G, et al. FEBS J, 2010 May. PMID 20412059
    5. Physiological truncation and domain organization of a novel uracil-DNA-degrading factor. Pukáncsik M, et al. FEBS J, 2010 Mar. PMID 20121948

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-strand selective uracil DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uracil DNA N-glycosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Single-strand-selective monofunctional uracil-DNA glycosylase
    Names
    CG5285-PA
    Smug-PA
    single-strand-specific UDG
    single-strand-specific monofunctional uracil-DNA glycosylase 1
    uracil-DNA glycosylase
    NP_650609.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17150587..17151630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142352.2 → NP_650609.1  Single-strand-selective monofunctional uracil-DNA glycosylase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QQ6, Q9VEM1
      Related
      FBpp0082850
      Conserved Domains (1) summary
      cl00483
      Location:39 → 270
      UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEM1 Q9VEM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous