U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MetRS-m Methionyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41733, updated on 8-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MetRS-mprovided by FlyBase
    Official Full Name
    Methionyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027083
    Locus tag
    Dmel_CG31322
    See related
    AllianceGenome:FB:FBgn0027083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-met; Aats-Met; Aats-met-m; CG31322; CG8684; CG9612; dMARS; Dmel\CG31322; MetRS; MRS
    Summary
    Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix. Is expressed in adult head and organism. Used to study mitochondrial metabolism disease and neurodegenerative disease. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MetRS-m in Genome Data Viewer
    Location:
    88B1-88B1; 3-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14249043..14259991, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10077105..10085713, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. Bayat V, et al. PLoS Biol, 2012. PMID 22448145, Free PMC Article
    2. Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina. Van Den Brink DM, et al. PLoS Genet, 2018 Sep. PMID 30199545, Free PMC Article
    3. 'Fly-ing' from rare to common neurodegenerative disease mechanisms. Ma M, et al. Trends Genet, 2022 Sep. PMID 35484057, Free PMC Article
    4. Pathways to neurodegeneration: lessons learnt from unbiased genetic screens in Drosophila. Singhal N, et al. J Genet, 2018 Jul. PMID 30027908
    5. Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Liu L, et al. Cell, 2015 Jan 15. PMID 25594180, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Aats-met in the eye results in retinal degeneration.
      Title: Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methionine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methionyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Methionyl-tRNA synthetase, mitochondrial
    Names
    CG31322-PA
    CG31322-PB
    CG31322-PC
    MetRS-m-PA
    MetRS-m-PB
    MetRS-m-PC
    Methionyl-tRNA synthetase
    mitochondrial methionyl-tRNA synthetase
    NP_001262564.1
    NP_001303507.1
    NP_650348.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14249043..14259991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316578.1 → NP_001303507.1  Methionyl-tRNA synthetase, mitochondrial, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KH54, Q8T0Q6, Q9VFL5
      Conserved Domains (3) summary
      cd00814
      Location:20 → 356
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      PRK11893
      Location:21 → 553
      PRK11893; methionyl-tRNA synthetase; Reviewed
      cl12020
      Location:365 → 503
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    2. NM_001275635.2 → NP_001262564.1  Methionyl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KH54, Q8T0Q6, Q9VFL5
      Conserved Domains (3) summary
      cd00814
      Location:20 → 356
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      PRK11893
      Location:21 → 553
      PRK11893; methionyl-tRNA synthetase; Reviewed
      cl12020
      Location:365 → 503
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    3. NM_142091.5 → NP_650348.1  Methionyl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650348.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KH54, Q8T0Q6, Q9VFL5
      Related
      FBpp0082356
      Conserved Domains (3) summary
      cd00814
      Location:20 → 356
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      PRK11893
      Location:21 → 553
      PRK11893; methionyl-tRNA synthetase; Reviewed
      cl12020
      Location:365 → 503
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFL5.2 Q9VFL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous