FAM103A1 family with sequence similarity 103 member A1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: FAM103A1provided by CGNC
Full Name: family with sequence similarity 103 member A1provided by CGNC
Primary source: CGNC:49987
See related: Ensembl:ENSGALG00010016607
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: RAMAC
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	10	NC_052541.1 (11191972..11197555)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	10	NC_052582.1 (11065260..11070823)

Chromosome 10 - NC_052541.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In humans FAM103A1, also known as RNA guanine-7 methyltransferase Activating Mini protein or RAM, has been shown to be required for efficient cap methylation of mRNA in vitro and in vivo and is indirectly required to maintain mRNA expression levels for mRNA translation and for cell viability.
Title: RAM/Fam103a1 is required for mRNA cap methylation.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA 5'-cap (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: RNA guanine-N7 methyltransferase activating subunit

Names: RNA guanine-7 methyltransferase activating subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277107.2 → NP_001264036.1 RNA guanine-N7 methyltransferase activating subunit

See identical proteins and their annotated locations for NP_001264036.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

JAENSK010000245

UniProtKB/TrEMBL

E1C6C2, R4GHY5

Conserved Domains (1) summary

pfam15320
Location:11 → 84

RAM; mRNA cap methylation, RNMT-activating mini protein
NM_001277108.2 → NP_001264037.1 RNA guanine-N7 methyltransferase activating subunit

See identical proteins and their annotated locations for NP_001264037.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

JAENSK010000245

UniProtKB/TrEMBL

E1C6C2, R4GHY5

Conserved Domains (1) summary

pfam15320
Location:11 → 84

RAM; mRNA cap methylation, RNMT-activating mini protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

11191972..11197555

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015291994.3 → XP_015147480.1 RNA guanine-N7 methyltransferase activating subunit isoform X1

UniProtKB/TrEMBL

E1C6C2, R4GHY5

Conserved Domains (1) summary

pfam15320
Location:11 → 84

RAM; mRNA cap methylation, RNMT-activating mini protein
XM_046899048.1 → XP_046755004.1 RNA guanine-N7 methyltransferase activating subunit isoform X2
XM_040706327.2 → XP_040562261.1 RNA guanine-N7 methyltransferase activating subunit isoform X1

UniProtKB/TrEMBL

E1C6C2, R4GHY5

Conserved Domains (1) summary

pfam15320
Location:11 → 84

RAM; mRNA cap methylation, RNMT-activating mini protein
XM_046899050.1 → XP_046755006.1 RNA guanine-N7 methyltransferase activating subunit isoform X1

UniProtKB/TrEMBL

E1C6C2, R4GHY5

Related

ENSGALP00010023190.1, ENSGALT00010040032.1
XM_046899049.1 → XP_046755005.1 RNA guanine-N7 methyltransferase activating subunit isoform X1

UniProtKB/TrEMBL

E1C6C2, R4GHY5

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

11065260..11070823

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046924853.1 → XP_046780809.1 RNA guanine-N7 methyltransferase activating subunit isoform X1

UniProtKB/TrEMBL

E1C6C2, R4GHY5
XM_046924854.1 → XP_046780810.1 RNA guanine-N7 methyltransferase activating subunit isoform X1

UniProtKB/TrEMBL

E1C6C2, R4GHY5
XM_046924855.1 → XP_046780811.1 RNA guanine-N7 methyltransferase activating subunit isoform X1

UniProtKB/TrEMBL

E1C6C2, R4GHY5
XM_046924851.1 → XP_046780807.1 RNA guanine-N7 methyltransferase activating subunit isoform X1

UniProtKB/TrEMBL

E1C6C2, R4GHY5
XM_046924852.1 → XP_046780808.1 RNA guanine-N7 methyltransferase activating subunit isoform X1

UniProtKB/TrEMBL

E1C6C2, R4GHY5