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    ATP8B ATPase 8B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41469, updated on 4-Apr-2024

    Summary

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    Official Symbol
    ATP8Bprovided by FlyBase
    Official Full Name
    ATPase 8Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037989
    Locus tag
    Dmel_CG14741
    See related
    AllianceGenome:FB:FBgn0037989
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atp8b; CG14741; dATP8B; DmCG14741; Dmel\CG14741
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in detection of chemical stimulus involved in sensory perception of smell and regulation of protein localization. Located in cilium and sensory dendrite. Is expressed in adult head and adult olfactory receptor neurons. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to several human genes including ATP8B2 (ATPase phospholipid transporting 8B2) and ATP8B4 (ATPase phospholipid transporting 8B4 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    87A7-87A8; 3-51 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12068375..12090612, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7894097..7916334, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene defective proboscis extension response 17 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling. Zhou Y, et al. Science, 2015 Aug 21. PMID 26293964, Free PMC Article
    2. Time-Dependent Odorant Sensitivity Modulation in Insects. Guo H, et al. Insects, 2022 Apr 2. PMID 35447796, Free PMC Article
    3. Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity. Danilov A, et al. Oncotarget, 2015 Aug 14. PMID 26305987, Free PMC Article
    4. Microvilli-derived extracellular vesicles carry Hedgehog morphogenic signals for Drosophila wing imaginal disc development. Hurbain I, et al. Curr Biol, 2022 Jan 24. PMID 34890558
    5. Lipid flippase modulates olfactory receptor expression and odorant sensitivity in Drosophila. Ha TS, et al. Proc Natl Acad Sci U S A, 2014 May 27. PMID 24821794, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sensory dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATPase 8B
    Names
    ATP8B-PB
    ATP8B-PC
    ATP8B-PD
    ATP8B-PF
    ATP8B-PG
    ATP8B-PH
    ATP8B-PI
    CG14741-PB
    CG14741-PC
    CG14741-PD
    CG14741-PF
    CG14741-PG
    CG14741-PH
    CG14741-PI
    NP_001247067.1
    NP_001247068.1
    NP_001247069.2
    NP_001287294.1
    NP_001287295.1
    NP_001287296.1
    NP_731669.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12068375..12090612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300365.1 → NP_001287294.1  ATPase 8B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH22
      Conserved Domains (5) summary
      TIGR01652
      Location:30 → 1169
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:482 → 576
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:16 → 81
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:915 → 1162
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:852 → 915
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001300367.1 → NP_001287296.1  ATPase 8B, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH79
      Conserved Domains (5) summary
      TIGR01652
      Location:30 → 1300
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:627 → 721
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:16 → 81
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1046 → 1293
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:983 → 1046
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    3. NM_001300366.1 → NP_001287295.1  ATPase 8B, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH21
      Conserved Domains (5) summary
      TIGR01652
      Location:30 → 1314
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:627 → 721
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:16 → 81
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1060 → 1307
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:997 → 1060
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    4. NM_001260140.2 → NP_001247069.2  ATPase 8B, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247069.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K756
      Conserved Domains (4) summary
      pfam13246
      Location:712 → 806
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:16 → 81
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1131 → 1378
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1068 → 1131
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    5. NM_001260138.2 → NP_001247067.1  ATPase 8B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247067.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K638
      Conserved Domains (4) summary
      pfam13246
      Location:712 → 806
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:16 → 81
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1145 → 1392
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1082 → 1145
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    6. NM_001260139.2 → NP_001247068.1  ATPase 8B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K669
      Conserved Domains (5) summary
      TIGR01652
      Location:209 → 1348
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:661 → 755
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:195 → 260
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1094 → 1341
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1031 → 1094
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    7. NM_169450.4 → NP_731669.2  ATPase 8B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731669.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGD4
      Conserved Domains (4) summary
      pfam13246
      Location:891 → 985
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:195 → 260
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1324 → 1571
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1261 → 1324
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K638 A0A0B4K638
    A0A0B4K669 A0A0B4K669
    A0A0B4K756 A0A0B4K756
    A0A0B4LH21 A0A0B4LH21
    A0A0B4LH22 A0A0B4LH22
    A0A0B4LH79 A0A0B4LH79
    Q9VGD4 Q9VGD4

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