lipf lipase, gastric [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lipfprovided by ZNC
Official Full Name: lipase, gastricprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2737
See related: Ensembl:ENSDARG00000018529 AllianceGenome:ZFIN:ZDB-GENE-040426-2737
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb73g06; zgc:56632; wu:fb73g06
Summary: Predicted to enable hydrolase activity, acting on ester bonds. Acts upstream of or within response to hypoxia. Is expressed in gill. Human ortholog(s) of this gene implicated in Wolman disease; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to human LIPA (lipase A, lysosomal acid type) and LIPF (lipase F, gastric type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (17158642..17201028, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (17036768..17079154, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gastric triacylglycerol lipase

NP_998569.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213404.1 → NP_998569.1 gastric triacylglycerol lipase precursor

See identical proteins and their annotated locations for NP_998569.1

Status: PROVISIONAL

Source sequence(s)

BC052131

UniProtKB/TrEMBL

Q7ZTR9

Related

ENSDARP00000026364.7, ENSDART00000020541.8

Conserved Domains (3) summary

PLN02872
Location:4 → 393

PLN02872; triacylglycerol lipase

pfam04083
Location:36 → 97

Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

pfam12695
Location:78 → 242

Abhydrolase_5; Alpha/beta hydrolase family