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    POT1 protection of telomeres 1 [ Gallus gallus (chicken) ]

    Gene ID: 404538, updated on 3-Apr-2024

    Summary

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    Symbol
    POT1provided by CGNC
    Full Name
    protection of telomeres 1provided by CGNC
    Primary source
    CGNC:6635
    See related
    Ensembl:ENSGALG00010001194
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (21910987..21978247)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (22164539..22231670)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109516 Neighboring gene zinc finger protein 800 Neighboring gene translation initiation factor IF-2-like Neighboring gene glutamate metabotropic receptor 8 Neighboring gene uncharacterized LOC112533160 Neighboring gene G protein-coupled receptor 37

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analyses of a single-stranded telomeric DNA binding domain of fission yeast pot1: conflict with X-ray crystallographic structure. Torigoe H, et al. Biosci Biotechnol Biochem, 2007 Feb. PMID 17284852
    2. Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Churikov D, et al. Mol Cell Biol, 2006 Sep. PMID 16943437, Free PMC Article
    3. Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1. Wei C, et al. Mol Cell Biol, 2004 Mar. PMID 14966288, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. an electrophoretic mobility shift assay and isothermal titration calorimetry analyses of the binding ability of the site-directed mutants indicated that only five amino acids significantly contributed to telomeric DNA recognition of Pot1
      Title: Mutational analyses of a single-stranded telomeric DNA binding domain of fission yeast pot1: conflict with X-ray crystallographic structure.
    2. These data indicate that vertebrate POT1 is required for telomere capping but that it functions quite differently from TRF2.
      Title: Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection.
    3. Endogenous chicken Pot1 is present at telomeres during periods of the cell cycle when t loops are thought to be present in DNA.
      Title: Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomerase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of telomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere capping IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of nuclear telomere cap complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protection of telomeres protein 1
    Names
    POT1 protection of telomeres 1 homolog
    POT1-like telomere end-binding protein
    cPot1
    protection of telomeres 1 homolog
    single-strand telomeric DNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_206992.1 → NP_996875.1  protection of telomeres protein 1

      See identical proteins and their annotated locations for NP_996875.1

      Status: PROVISIONAL

      Source sequence(s)
      AY555718
      UniProtKB/Swiss-Prot
      P62597
      UniProtKB/TrEMBL
      A0A8V0X4I9
      Conserved Domains (2) summary
      smart00976
      Location:155 → 285
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd04498
      Location:305 → 421
      hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      21910987..21978247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025147065.3 → XP_025002833.2  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0X4I9, A0A8V0X9W7
      Related
      ENSGALP00010001310.1, ENSGALT00010002760.1
      Conserved Domains (3) summary
      smart00976
      Location:155 → 285
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd04498
      Location:305 → 421
      hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
      cd20374
      Location:485 → 773
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

    2. XM_015280911.4 → XP_015136397.3  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0X4I9, A0A8V0X9W7
      Related
      ENSGALP00010001309.1, ENSGALT00010002759.1
      Conserved Domains (3) summary
      smart00976
      Location:155 → 285
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd04498
      Location:305 → 421
      hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
      cd20374
      Location:485 → 773
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

    3. XM_025147062.3 → XP_025002830.2  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0X4I9, A0A8V0X9W7
      Conserved Domains (3) summary
      smart00976
      Location:155 → 285
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd04498
      Location:305 → 421
      hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
      cd20374
      Location:485 → 773
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

    4. XM_015280913.4 → XP_015136399.3  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0X4I9, A0A8V0X9W7
      Conserved Domains (3) summary
      smart00976
      Location:155 → 285
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd04498
      Location:305 → 421
      hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
      cd20374
      Location:485 → 773
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

    5. XM_040674038.2 → XP_040529972.1  protection of telomeres protein 1 isoform X2

      Conserved Domains (3) summary
      smart00976
      Location:6 → 105
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd04498
      Location:125 → 241
      hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
      cd20374
      Location:305 → 593
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      22164539..22231670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906981.1 → XP_046762937.1  protection of telomeres protein 1 isoform X3

    2. XM_046906979.1 → XP_046762935.1  protection of telomeres protein 1 isoform X3

    3. XM_046906980.1 → XP_046762936.1  protection of telomeres protein 1 isoform X3

    4. XM_046906982.1 → XP_046762938.1  protection of telomeres protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P62597

    5. XM_046906983.1 → XP_046762939.1  protection of telomeres protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P62597
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62597.1 GenPept UniProtKB/Swiss-Prot:P62597

    Gene LinkOut

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