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    GUSB glucuronidase beta [ Canis lupus familiaris (dog) ]

    Gene ID: 403831, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GUSBprovided by VGNC
    Official Full Name
    glucuronidase betaprovided by VGNC
    Primary source
    VGNC:VGNC:54034
    See related
    Ensembl:ENSCAFG00845013255
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 6
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (535764..548724, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (2430980..2444321, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (644508..657770, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (479152..492513, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (473517..486454, complement)

    Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene vitamin K epoxide reductase complex subunit 1 like 1 Neighboring gene microtubule-associated protein RP/EB family member 1-like Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) pseudogene Neighboring gene uncharacterized LOC119872315

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel GUSB mutation in Brazilian terriers with severe skeletal abnormalities defines the disease as mucopolysaccharidosis VII. Hytönen MK, et al. PLoS One, 2012. PMID 22815736, Free PMC Article
    2. Cloning of the canine beta-glucuronidase cDNA, mutation identification in canine MPS VII, and retroviral vector-mediated correction of MPS VII cells. Ray J, et al. Genomics, 1998 Mar 1. PMID 9521879
    3. Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library. Li R, et al. Genomics, 1999 May 15. PMID 10331940

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a novel genetic defect in the Brazilian Terrier breed causing a congenital skeletal dysplasia
      Title: A novel GUSB mutation in Brazilian terriers with severe skeletal abnormalities defines the disease as mucopolysaccharidosis VII.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables beta-glucuronidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glucuronoside catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-glucuronidase
    NP_001003191.1
    XP_038523481.1
    XP_038523482.1
    XP_038523483.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003191.1 → NP_001003191.1  beta-glucuronidase precursor

      See identical proteins and their annotated locations for NP_001003191.1

      Status: PROVISIONAL

      Source sequence(s)
      AF019759
      UniProtKB/Swiss-Prot
      O18835
      UniProtKB/TrEMBL
      A0A8I3NPA0
      Related
      ENSCAFP00845018552.1, ENSCAFT00845023635.1
      Conserved Domains (1) summary
      cl27651
      Location:27 → 630
      Glyco_hydro_2; Glycosyl hydrolases family 2

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051810.1 Reference ROS_Cfam_1.0

      Range
      535764..548724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038667553.1 → XP_038523481.1  beta-glucuronidase isoform X1

      UniProtKB/TrEMBL
      A0A8I3NPA0
      Conserved Domains (1) summary
      cl30613
      Location:1 → 554
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

    2. XM_038667554.1 → XP_038523482.1  beta-glucuronidase isoform X2

      Conserved Domains (1) summary
      cl30613
      Location:6 → 441
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

    3. XM_038667555.1 → XP_038523483.1  beta-glucuronidase isoform X3

      Conserved Domains (1) summary
      cl30613
      Location:20 → 412
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049266.1 Alternate UMICH_Zoey_3.1

      Range
      479152..492513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

      Range
      473517..486454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

      Range
      644508..657770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      2430980..2444321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18835.1 GenPept UniProtKB/Swiss-Prot:O18835

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