HGFAC HGF activator [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HGFACprovided by VGNC
Official Full Name: HGF activatorprovided by VGNC
Primary source: VGNC:VGNC:41675
See related: Ensembl:ENSCAFG00845010920
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: HGFA
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	3	NC_051807.1 (61382412..61390658, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	3	NC_006585.4 (63557017..63565265, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	3	NC_049224.1 (61436631..61444882, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	3	NC_049263.1 (60874179..60882422, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	3	NC_049744.1 (61080281..61088528, complement)

Chromosome 3 - NC_051807.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in zymogen activation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in rough endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hepatocyte growth factor activator

NP_001026985.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031815.2 → NP_001026985.1 hepatocyte growth factor activator precursor

See identical proteins and their annotated locations for NP_001026985.1

Status: PROVISIONAL

Source sequence(s)

AY532633

UniProtKB/Swiss-Prot

Q6QNF4

UniProtKB/TrEMBL

A0A8I3NIY8

Related

ENSCAFP00845015085.1, ENSCAFT00845019299.1

Conserved Domains (6) summary

smart00059
Location:100 → 146

FN2; Fibronectin type 2 domain

smart00020
Location:406 → 640

Tryp_SPc; Trypsin-like serine protease

cd00054
Location:160 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00061
Location:198 → 238

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00190
Location:407 → 642

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00051
Location:284 → 365

Kringle; Kringle domain