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    cyp2p10 cytochrome P450, family 2, subfamily P, polypeptide 10 [ Danio rerio (zebrafish) ]

    Gene ID: 399485, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cyp2p10provided by ZNC
    Official Full Name
    cytochrome P450, family 2, subfamily P, polypeptide 10provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040120-1
    See related
    Ensembl:ENSDARG00000042990 AllianceGenome:ZFIN:ZDB-GENE-040120-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cyp2j21; cyp2j2a
    Summary
    Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in nervous system; neural plate; neural rod; neural tube; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (25586235..25593741)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (25687145..25694611)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily P, polypeptide 8 Neighboring gene cytochrome P450, family 2, subfamily P, polypeptide 9 Neighboring gene uncharacterized LOC110438177 Neighboring gene cytochrome P450, family 2, subfamily J, polypeptide 20 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish. Jia D, et al. Cell Death Dis, 2022 Nov 17. PMID 36396940, Free PMC Article
    2. Phylogenetic and functional analysis of the vertebrate cytochrome p450 2 family. Kirischian N, et al. J Mol Evol, 2011 Jan. PMID 21116621
    3. Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[α]P, BPA, OP, and NP. Puthumana J, et al. Aquat Toxicol, 2017 Jun. PMID 28411468
    4. Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Li ZH, et al. Mol Biosyst, 2011 Jul. PMID 21445457
    5. Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. Goldstone JV, et al. BMC Genomics, 2010 Nov 18. PMID 21087487, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 2P10; cytochrome P450, family 2, subfamily P, polypeptide 10
    Names
    cytochrome P450, family 2, subfamily J, polypeptide 2, A
    cytochrome P450, family 2, subfamily J, polypeptide 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201511.1 → NP_958919.1  cytochrome P450 2P10

      See identical proteins and their annotated locations for NP_958919.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049521
      UniProtKB/TrEMBL
      Q7ZU60
      Related
      ENSDARP00000063121.4, ENSDART00000063122.5
      Conserved Domains (1) summary
      pfam00067
      Location:38 → 493
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      25586235..25593741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299950.3 → XP_009298225.1  cytochrome P450, family 2, subfamily P, polypeptide 10 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B1F6
      Conserved Domains (1) summary
      pfam00067
      Location:62 → 334
      p450; Cytochrome P450

    2. XM_005160559.4 → XP_005160616.1  cytochrome P450, family 2, subfamily P, polypeptide 10 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B7E8
      Conserved Domains (1) summary
      pfam00067
      Location:9 → 278
      p450; Cytochrome P450

    RNA

    1. XR_001796701.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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