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    ZP4 zona pellucida glycoprotein 4 [ Sus scrofa (pig) ]

    Gene ID: 397111, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZP4provided by VGNC
    Official Full Name
    zona pellucida glycoprotein 4provided by VGNC
    Primary source
    VGNC:VGNC:95319
    See related
    Ensembl:ENSSSCG00000010141
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    ZPB; Zp-4; ZP3-ALPHA
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Restricted expression toward ovary (RPKM 80.8) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (53577138..53584544)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (57496103..57503521)

    Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene mitochondrial intermediate peptidase-like Neighboring gene protein CEBPZOS-like Neighboring gene uncharacterized LOC110256642 Neighboring gene isochorismatase domain-containing protein 1-like Neighboring gene ryanodine receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Porcine zona pellucida glycoprotein ZP4 is responsible for the sperm-binding activity of the ZP3/ZP4 complex. Yonezawa N, et al. Zygote, 2012 Nov. PMID 22008510
    2. Localization of carbohydrate chains of pig sperm ligand in the glycoprotein ZPB of egg zona pellucida. Kudo K, et al. Eur J Biochem, 1998 Mar 15. PMID 9546665
    3. Nucleotide sequence of cDNA encoding ZP3 alpha, a sperm-binding glycoprotein from zona pellucida of pig oocyte. Yurewicz EC, et al. Biochim Biophys Acta, 1993 Aug 19. PMID 8357839
    4. Identification of the carboxyl termini of porcine zona pellucida glycoproteins ZPB and ZPC. Yonezawa N, et al. Biochem Biophys Res Commun, 2003 Aug 8. PMID 12878193
    5. Porcine oocyte zona pellucida M(r) 55,000 glycoproteins: identification of O-glycosylated domains. Yurewicz EC, et al. Mol Reprod Dev, 1992 Oct. PMID 1418987

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Porcine zona pellucida glycoprotein ZP4 is responsible for the sperm-binding activity of the ZP3/ZP4 complex
      Title: Porcine zona pellucida glycoprotein ZP4 is responsible for the sperm-binding activity of the ZP3/ZP4 complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acrosin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of egg coat IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in prevention of polyspermy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in egg coat IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zona pellucida sperm-binding protein 4
    Names
    zona pellucida glycoprotein 3-alpha
    zona pellucida glycoprotein ZP3-alpha
    zona pellucida protein 3-alpha
    zona pellucida protein B
    zp-3-alpha
    zp3-alpha sperm-binding glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214045.1 → NP_999210.1  zona pellucida sperm-binding protein 4 precursor

      See identical proteins and their annotated locations for NP_999210.1

      Status: PROVISIONAL

      Source sequence(s)
      L11000
      UniProtKB/Swiss-Prot
      Q07287
      UniProtKB/TrEMBL
      A0A480KPP2, A0A8D1GYF0
      Related
      ENSSSCP00000010814.2, ENSSSCT00000011102.4
      Conserved Domains (3) summary
      smart00018
      Location:146 → 186
      PD; P or trefoil or TFF domain
      smart00241
      Location:189 → 460
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:323 → 460
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

      Range
      53577138..53584544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07287.1 GenPept UniProtKB/Swiss-Prot:Q07287

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.