CST3 cystatin C [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CST3provided by CGNC
Official Full Name: cystatin Cprovided by CGNC
Primary source: CGNC:49837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (15278759..15281084)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (15168280..15195318)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The I108T mutant, which exhibited larger secondary structural fluctuations and hydrophobic core expanding tendency compared with the wild-type chicken cystatin, is a new amyloidogenic form of chicken cystatin.
Title: Structural and dynamic properties of a new amyloidogenic chicken cystatin mutant I108T.
In calvarial bone explants egg white cystatin decreases calcium release into the medium significantly.
Title: Family 2 cystatins inhibit osteoclast-mediated bone resorption in calvarial bone explants.
Data show that, under conditions leading to the formation of amyloid deposits, the domain-swapped dimer of chicken cystatin further oligomerizes to a tetramer, prior to fibrillization.
Title: Cystatin forms a tetramer through structural rearrangement of domain-swapped dimers prior to amyloidogenesis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cystatin

Names: egg-white cystatin; ovocystatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205500.3 → NP_990831.2 cystatin precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000062

UniProtKB/Swiss-Prot

P01038

Conserved Domains (1) summary

smart00043
Location:41 → 151

CY; Cystatin-like domain