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    LBR lamin B receptor [ Gallus gallus (chicken) ]

    Gene ID: 396285, updated on 3-Apr-2024

    Summary

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    Symbol
    LBRprovided by CGNC
    Full Name
    lamin B receptorprovided by CGNC
    Primary source
    CGNC:49736
    See related
    Ensembl:ENSGALG00010016460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    C14SR; TM7SF2
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    See LBR in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (17091995..17113148)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (17007081..17028198)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107052962 Neighboring gene ENAH actin regulator Neighboring gene signal recognition particle 9 Neighboring gene uncharacterized LOC121110401 Neighboring gene uncharacterized LOC101748007 Neighboring gene dynein, axonemal, heavy chain 14 Neighboring gene cornichon family AMPA receptor auxiliary protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The lamin B receptor of the nuclear envelope inner membrane: a polytopic protein with eight potential transmembrane domains. Worman HJ, et al. J Cell Biol, 1990 Oct. PMID 2170422, Free PMC Article
    2. Solution structure and molecular interactions of lamin B receptor Tudor domain. Liokatis S, et al. J Biol Chem, 2012 Jan 6. PMID 22052904, Free PMC Article
    3. An expressed sequence tag analysis of the chicken reproductive tract transcriptome. Froman DP, et al. Poult Sci, 2006 Aug. PMID 16903475
    4. A large database of chicken bursal ESTs as a resource for the analysis of vertebrate gene function. Abdrakhmanov I, et al. Genome Res, 2000 Dec. PMID 11116100, Free PMC Article
    5. Development of a chicken 5 K microarray targeted towards immune function. Smith J, et al. BMC Genomics, 2006 Mar 13. PMID 16533398, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    delta(14)-sterol reductase LBR
    Names
    3-beta-hydroxysterol Delta (14)-reductase
    C-14 sterol reductase
    delta-14-SR
    integral nuclear envelope inner membrane protein
    sterol C14-reductase
    transmembrane 7 superfamily member 2
    NP_001383068.1
    XP_015139112.1
    XP_015139114.1
    XP_015139115.1
    XP_040552803.1
    XP_040552804.1
    XP_040552805.1
    XP_046769192.1
    XP_046769193.1
    XP_046769194.1
    XP_046769195.1
    XP_046769196.1
    XP_046769197.1
    XP_046769198.1
    XP_046794491.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396139.1 → NP_001383068.1  delta(14)-sterol reductase LBR

      Status: VALIDATED

      Source sequence(s)
      AJ394105, AM065519, BQ037267, BQ037683, BU112213, BX934238, DT654835, HAEL01001965, HAEL01010832, Y00822
      UniProtKB/TrEMBL
      A0A8V0YPJ6, A0A8V0Z2T6
      Related
      ENSGALP00010022917.1, ENSGALT00010039658.1
      Conserved Domains (2) summary
      pfam01222
      Location:175 → 608
      ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
      pfam09465
      Location:1 → 55
      LBR_tudor; Lamin-B receptor of TUDOR domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      17091995..17113148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046938535.1 → XP_046794491.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8V0YXW8

    2. XM_040696869.2 → XP_040552803.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8V0YWC9, A0A8V0YXW8
      Conserved Domains (2) summary
      pfam01222
      Location:198 → 631
      ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
      pfam09465
      Location:24 → 78
      LBR_tudor; Lamin-B receptor of TUDOR domain

    3. XM_015283626.4 → XP_015139112.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8V0YWC9, A0A8V0YXW8
      Related
      ENSGALP00010022920.1, ENSGALT00010039661.1
      Conserved Domains (2) summary
      pfam01222
      Location:198 → 631
      ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
      pfam09465
      Location:24 → 78
      LBR_tudor; Lamin-B receptor of TUDOR domain

    4. XM_040696870.2 → XP_040552804.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8V0YWC9, A0A8V0YXW8
      Related
      ENSGALP00010022909.1, ENSGALT00010039650.1
      Conserved Domains (2) summary
      pfam01222
      Location:198 → 631
      ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
      pfam09465
      Location:24 → 78
      LBR_tudor; Lamin-B receptor of TUDOR domain

    5. XM_015283628.4 → XP_015139114.1  delta(14)-sterol reductase LBR isoform X3

      UniProtKB/TrEMBL
      A0A8V0YPJ6, A0A8V0Z2T6
      Related
      ENSGALP00010022916.1, ENSGALT00010039657.1
      Conserved Domains (2) summary
      pfam01222
      Location:175 → 608
      ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
      pfam09465
      Location:1 → 55
      LBR_tudor; Lamin-B receptor of TUDOR domain

    6. XM_040696871.2 → XP_040552805.1  delta(14)-sterol reductase LBR isoform X2

      UniProtKB/TrEMBL
      A0A8V0YVY0, A0A8V0YWC9
      Related
      ENSGALP00010022908.1, ENSGALT00010039649.1
      Conserved Domains (1) summary
      pfam01222
      Location:181 → 614
      ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family

    7. XM_015283629.4 → XP_015139115.1  delta(14)-sterol reductase LBR isoform X3

      UniProtKB/TrEMBL
      A0A8V0YPJ6, A0A8V0Z2T6
      Conserved Domains (2) summary
      pfam01222
      Location:175 → 608
      ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
      pfam09465
      Location:1 → 55
      LBR_tudor; Lamin-B receptor of TUDOR domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      17007081..17028198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046913237.1 → XP_046769193.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8V0YXW8

    2. XM_046913238.1 → XP_046769194.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8V0YXW8

    3. XM_046913236.1 → XP_046769192.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8V0YXW8

    4. XM_046913241.1 → XP_046769197.1  delta(14)-sterol reductase LBR isoform X3

      UniProtKB/TrEMBL
      A0A8V0YPJ6

    5. XM_046913242.1 → XP_046769198.1  delta(14)-sterol reductase LBR isoform X3

      UniProtKB/TrEMBL
      A0A8V0YPJ6

    6. XM_046913239.1 → XP_046769195.1  delta(14)-sterol reductase LBR isoform X2

      UniProtKB/TrEMBL
      A0A8V0YVY0

    7. XM_046913240.1 → XP_046769196.1  delta(14)-sterol reductase LBR isoform X3

      UniProtKB/TrEMBL
      A0A8V0YPJ6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_205342.1: Suppressed sequence

      Description
      NM_205342.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23913.1 GenPept UniProtKB/Swiss-Prot:P23913

    Gene LinkOut

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