VTN vitronectin [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: VTNprovided by CGNC
Official Full Name: vitronectinprovided by CGNC
Primary source: CGNC:2621
See related: Ensembl:ENSGALG00010029410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	19	NC_052550.1 (6128499..6133429, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	19	NC_052591.1 (5865004..5869934, complement)

Chromosome 19 - NC_052550.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings provide the first evidence for a potential role of the insulin-like growth factor II -vitronectin complex during the endothelial-to-mesenchymal transition process
Title: Potential role for insulin-like growth factor II and vitronectin in the endothelial-mesenchymal transition process.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info	PubMed
enables polysaccharide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: vitronectin

Names: complement S-protein); somatomedin B; vitronectin (serum spreading factor, somatomedin B, complement S-protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001397127.1 → NP_001384056.1 vitronectin precirsor precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000323

UniProtKB/TrEMBL

A0A8V1AM36, O12945

Related

ENSGALP00010043832.1, ENSGALT00010071141.1

Conserved Domains (2) summary

smart00201
Location:19 → 61

SO; Somatomedin B -like domains

cd00094
Location:152 → 445

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
NM_205061.2 → NP_990392.1 vitronectin precursor

See identical proteins and their annotated locations for NP_990392.1

Status: VALIDATED

Source sequence(s)

JAENSK010000323

UniProtKB/TrEMBL

A0A8V1AM36, O12945

Related

ENSGALP00010043831.1, ENSGALT00010071140.1

Conserved Domains (2) summary

smart00201
Location:19 → 61

SO; Somatomedin B -like domains

cd00094
Location:152 → 445

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

6128499..6133429 complement

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GenBank, FASTA, Sequence Viewer (Graphics)