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    ephx1 epoxide hydrolase 1, microsomal (xenobiotic) [ Danio rerio (zebrafish) ]

    Gene ID: 394043, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ephx1provided by ZNC
    Official Full Name
    epoxide hydrolase 1, microsomal (xenobiotic)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-913
    See related
    Ensembl:ENSDARG00000042854 AllianceGenome:ZFIN:ZDB-GENE-040426-913
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56126
    Summary
    Predicted to enable epoxide hydrolase activity. Predicted to be involved in epoxide metabolic process. Predicted to act upstream of or within response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (36628274..36638179)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (36725395..36735300)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene ENAH actin regulator Neighboring gene signal recognition particle 9 Neighboring gene solute carrier family 5 member 6a Neighboring gene ribosomal protein L7-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Time-Related Alteration of Aqueous-Phase Anthracene and Phenanthrene Photoproducts in the Presence of TiO(2) Nanoparticles. St Mary L, et al. Environ Sci Technol, 2021 Mar 16. PMID 33651588, Free PMC Article
    2. Co-exposure to environmental carcinogens in vivo induces neoplasia-related hallmarks in low-genotoxicity events, even after removal of insult. Martins M, et al. Sci Rep, 2018 Feb 26. PMID 29483554, Free PMC Article
    3. Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. Falfushynska H, et al. Water Res, 2021 Apr 15. PMID 33631698
    4. Comprehensive understanding of PM(2.5) on gene and microRNA expression patterns in zebrafish (Danio rerio) model. Duan J, et al. Sci Total Environ, 2017 May 15. PMID 28215799
    5. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Yin HM, et al. Sci Adv, 2020 May. PMID 32494702, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56126

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-stilbene-oxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epoxide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ether hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aromatic compound catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic compound catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epoxide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epoxide hydrolase 1
    NP_957362.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201068.1 → NP_957362.1  epoxide hydrolase 1

      See identical proteins and their annotated locations for NP_957362.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045930
      UniProtKB/TrEMBL
      Q7ZVB4
      Related
      ENSDARP00000062897.3, ENSDART00000062898.6
      Conserved Domains (3) summary
      COG0596
      Location:114 → 450
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam06441
      Location:50 → 152
      EHN; Epoxide hydrolase N terminus
      cl21494
      Location:124 → 283
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      36628274..36638179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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