lias lipoic acid synthetase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: liasprovided by ZNC
Official Full Name: lipoic acid synthetaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1528
See related: Ensembl:ENSDARG00000022845 AllianceGenome:ZFIN:ZDB-GENE-040426-1528
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: LS; zgc:66080
Summary: Predicted to enable lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (23274732..23283465)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (22583993..22592726)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables lipoate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipoate synthase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipoate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipoate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipoyl synthase, mitochondrial

NP_001103871.1

EC 2.8.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110401.1 → NP_001103871.1 lipoyl synthase, mitochondrial

See identical proteins and their annotated locations for NP_001103871.1

Status: PROVISIONAL

Source sequence(s)

BC154781

UniProtKB/Swiss-Prot

A8WGN4, Q6PHG4

UniProtKB/TrEMBL

A0A0R4I9B1

Related

ENSDARP00000035286.7, ENSDART00000036448.8

Conserved Domains (3) summary

cd01335
Location:154 → 330

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

PLN02428
Location:58 → 394

PLN02428; lipoic acid synthase

pfam16881
Location:53 → 131

LIAS_N; N-terminal domain of lipoyl synthase of Radical_SAM family