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    CG32374 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38848, updated on 29-Dec-2023

    Summary

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    Official Symbol
    CG32374provided by FlyBase
    Primary source
    FLYBASE:FBgn0052374
    Locus tag
    Dmel_CG32374
    See related
    AllianceGenome:FB:FBgn0052374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8528; Dmel\CG32374; SP148; SP148a
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36); PRSS53 (serine protease 53); and PRSS57 (serine protease 57). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    66A5-66A5; 3-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7540269..7541168, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7533369..7534268, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene larval translucida Neighboring gene liquid facets Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional dissection of an innate immune response by a genome-wide RNAi screen. Foley E, et al. PLoS Biol, 2004 Aug. PMID 15221030, Free PMC Article
    2. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400
    3. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721
    4. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article
    5. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32374-PA
    NP_729270.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7540269..7541168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168222.1 → NP_729270.1  uncharacterized protein Dmel_CG32374 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VS87
      Related
      FBpp0076539, FBtr0076828
      Conserved Domains (2) summary
      smart00020
      Location:73 → 292
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:74 → 295
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS87 Q9VS87

    Gene LinkOut

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