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    Srp19 Signal recognition particle 19 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38815, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Srp19provided by FlyBase
    Official Full Name
    Signal recognition particle 19provided by FlyBase
    Primary source
    FLYBASE:FBgn0015298
    Locus tag
    Dmel_CG4457
    See related
    AllianceGenome:FB:FBgn0015298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4457; Dmel\CG4457; srp19; SRP19
    Summary
    Predicted to enable 7S RNA binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in several structures, including adult heart; embryonic/larval digestive system; foregut primordium; hindgut proper primordium; and presumptive embryonic/larval digestive system. Orthologous to human SRP19 (signal recognition particle 19). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    65F5-65F5; 3-20 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7347310..7348034, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7340410..7341134, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lark Neighboring gene Cln7 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45833 Neighboring gene quemao Neighboring gene CTCF Neighboring gene antisense RNA:CR45822

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster. Lai C, et al. Gene, 1997 Dec 5. PMID 9426007
    2. quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthase. Lai C, et al. Genetics, 1998 Jun. PMID 9611212, Free PMC Article
    3. Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling. Schroeder AM, et al. PLoS Genet, 2022 Oct. PMID 36240221, Free PMC Article
    4. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Fox RM, et al. J Cell Biol, 2010 Nov 1. PMID 21041443, Free PMC Article
    5. CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. Abrams EW, et al. Development, 2005 Jun. PMID 15901661

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of signal recognition particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle 19
    Names
    CG4457-PA
    Srp19-PA
    signal recognition particle 19 kD protein
    signal recognition particle protein 19

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7347310..7348034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057787.5 → NP_477135.2  signal recognition particle 19 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477135.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49963, Q9VS53
      UniProtKB/TrEMBL
      A0A1B2AKI4
      Related
      FBpp0076589
      Conserved Domains (1) summary
      pfam01922
      Location:25 → 122
      SRP19; SRP19 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49963.2 P49963

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