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    elf2b E74-like factor 2b (ets domain transcription factor) [ Danio rerio (zebrafish) ]

    Gene ID: 387534, updated on 11-Apr-2024

    Summary

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    Official Symbol
    elf2bprovided by ZNC
    Official Full Name
    E74-like factor 2b (ets domain transcription factor)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031215-1
    See related
    Ensembl:ENSDARG00000079626 AllianceGenome:ZFIN:ZDB-GENE-031215-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ef2; elf2; zef2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in endothelial cell. Orthologous to human ELF2 (E74 like ETS transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (13957218..13989498, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (13270705..13302998, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886839 Neighboring gene nocturnin b Neighboring gene mitochondria localized glutamic acid rich protein b Neighboring gene histone PARylation factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Radiation hybrid mapping of the zebrafish genome. Hukriede NA, et al. Proc Natl Acad Sci U S A, 1999 Aug 17. PMID 10449765, Free PMC Article
    2. Zebrafish Dnd protein binds to 3'UTR of geminin mRNA and regulates its expression. Chen S, et al. BMB Rep, 2010 Jun. PMID 20587335
    3. Vertebrate genome evolution and the zebrafish gene map. Postlethwait JH, et al. Nat Genet, 1998 Apr. PMID 9537416
    4. Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis. Liu F, et al. Circ Res, 2008 Nov 7. PMID 18832752
    5. ETS factors regulate Vegf-dependent arterial specification. Wythe JD, et al. Dev Cell, 2013 Jul 15. PMID 23830865, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ETS-related transcription factor Elf-2; ETS-related transcription factor Elf-2b
    Names
    E74-like factor 2 (ets domain transcription factor)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199219.2 → NP_954689.1  ETS-related transcription factor Elf-2b

      See identical proteins and their annotated locations for NP_954689.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056554
      UniProtKB/TrEMBL
      Q6PHH1
      Related
      ENSDARP00000094160.3, ENSDART00000103383.5
      Conserved Domains (2) summary
      pfam00178
      Location:146 → 225
      Ets; Ets-domain
      pfam12310
      Location:14 → 46
      Elf-1_N; Transcription factor protein N terminal

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      13957218..13989498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159828.2 → XP_005159885.1  ETS-related transcription factor Elf-2 isoform X1

      See identical proteins and their annotated locations for XP_005159885.1

      UniProtKB/TrEMBL
      A0A2R8QIV0, A0A8M2B6L8
      Related
      ENSDARP00000154068.1, ENSDART00000191046.1
      Conserved Domains (2) summary
      pfam00178
      Location:221 → 300
      Ets; Ets-domain
      pfam12310
      Location:4 → 121
      Elf-1_N; Transcription factor protein N terminal

    2. XM_005159829.4 → XP_005159886.1  ETS-related transcription factor Elf-2 isoform X1

      See identical proteins and their annotated locations for XP_005159886.1

      UniProtKB/TrEMBL
      A0A2R8QIV0, A0A8M2B6L8
      Conserved Domains (2) summary
      pfam00178
      Location:221 → 300
      Ets; Ets-domain
      pfam12310
      Location:4 → 121
      Elf-1_N; Transcription factor protein N terminal

    3. XM_005159830.4 → XP_005159887.1  ETS-related transcription factor Elf-2 isoform X1

      See identical proteins and their annotated locations for XP_005159887.1

      UniProtKB/TrEMBL
      A0A2R8QIV0, A0A8M2B6L8
      Conserved Domains (2) summary
      pfam00178
      Location:221 → 300
      Ets; Ets-domain
      pfam12310
      Location:4 → 121
      Elf-1_N; Transcription factor protein N terminal

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394465.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      164749..175684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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