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    grp78 glucose regulated protein 78 [ Neurospora crassa OR74A ]

    Gene ID: 3872714, updated on 25-Jan-2024

    Summary

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    Gene symbol
    grp78
    Gene description
    glucose regulated protein 78
    Locus tag
    NCU03982
    Gene type
    protein coding
    RNA name
    glucose-regulated protein
    RefSeq status
    PROVISIONAL
    Organism
    Neurospora crassa OR74A (strain: OR74A)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora
    Also known as
    hsps-2
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    Genomic context

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    Location:
    other: VI
    Exon count:
    6
    Sequence:
    Chromosome: VI; NC_026506.1 (2329825..2332792)

    Linkage Group VI - NC_026506.1Genomic Context describing neighboring genes Neighboring gene T-complex protein 1 subunit epsilon Neighboring gene elongation factor Tu GTP binding domain-containing protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_026506.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Liposomal co-delivery-based quantitative evaluation of chemosensitivity enhancement in breast cancer stem cells by knockdown of GRP78/CLU. Samson AAS, et al. J Liposome Res, 2019 Mar. PMID 29262741
    2. The association of variants in PNPLA3 and GRP78 and the risk of developing hepatocellular carcinoma in an Italian population. Balasus D, et al. Oncotarget, 2016 Dec 27. PMID 27888630, Free PMC Article
    3. The genome sequence of the filamentous fungus Neurospora crassa. Galagan JE, et al. Nature, 2003 Apr 24. PMID 12712197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the present study, chemo-resistant proteins, including glucose-regulated protein 78 (GRP78)/clusterin (CLU) targeted 1,2-dioleoyloxy-3-trimethylammoniumpropane (DOTAP) liposomes, were developed as a delivery system for co-delivery of camptothecin (CPT) and GRP78 siRNA/CLU siRNA.
      Title: Liposomal co-delivery-based quantitative evaluation of chemosensitivity enhancement in breast cancer stem cells by knockdown of GRP78/CLU.
    2. Two single nucleotide polymorphisms (SNPs), rs430397 in glucose regulated protein 78 kDa (GRP78) and rs738409 in patatin-like phospholipase domain-containing 3 protein (PNPLA3), were shown to be significantly associated with the risk of developing hepatocellular carcinoma (HCC) in a Sicilian population.
      Title: The association of variants in PNPLA3 and GRP78 and the risk of developing hepatocellular carcinoma in an Italian population.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables misfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chaperone cofactor-dependent protein refolding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of endoplasmic reticulum chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Names
    glucose-regulated protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_026506.1 Reference assembly

      Range
      2329825..2332792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_951474.3 → XP_956567.1  glucose-regulated protein [Neurospora crassa OR74A]

      See identical proteins and their annotated locations for XP_956567.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78695, Q7RV55
      UniProtKB/TrEMBL
      A0A0B0DZU7
      Conserved Domains (1) summary
      pfam00012
      Location:41 → 645
      HSP70; Hsp70 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78695.3

    Gene LinkOut

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    Molecular Biology Databases