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    Tsen2 tRNA splicing endonuclease subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 381802, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tsen2provided by MGI
    Official Full Name
    tRNA splicing endonuclease subunit 2provided by MGI
    Primary source
    MGI:MGI:2141599
    See related
    Ensembl:ENSMUSG00000042389 AllianceGenome:MGI:2141599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to act upstream of or within mRNA processing and tRNA processing. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.3), CNS E14 (RPKM 5.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 E3; 6 53.58 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115521652..115555297)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115544659..115578350)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36301 Neighboring gene predicted gene, 36355 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115510052-115510235 Neighboring gene STARR-seq mESC enhancer starr_17082 Neighboring gene STARR-positive B cell enhancer mm9_chr6:115533495-115533796 Neighboring gene makorin, ring finger protein 2, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115551710-115551893 Neighboring gene makorin, ring finger protein, 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115570008-115570117 Neighboring gene v-raf-leukemia viral oncogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. Bopp SE, et al. PLoS One, 2010 May 28. PMID 20531941, Free PMC Article
    2. TRF2-mediated telomere protection is dispensable in pluripotent stem cells. Markiewicz-Potoczny M, et al. Nature, 2021 Jan. PMID 33239785, Free PMC Article
    3. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC69703

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-intron endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA-intron endonuclease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-splicing endonuclease subunit Sen2
    Names
    tRNA splicing endonuclease 2 homolog
    tRNA-intron endonuclease Sen2
    NP_001398713.1
    NP_001398714.1
    NP_001398715.1
    NP_950198.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411784.1 → NP_001398713.1  tRNA-splicing endonuclease subunit Sen2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153828

    2. NM_001411785.1 → NP_001398714.1  tRNA-splicing endonuclease subunit Sen2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153828

    3. NM_001411786.1 → NP_001398715.1  tRNA-splicing endonuclease subunit Sen2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153828

    4. NM_199033.3 → NP_950198.1  tRNA-splicing endonuclease subunit Sen2 isoform 1

      See identical proteins and their annotated locations for NP_950198.1

      Status: VALIDATED

      Source sequence(s)
      AC153828
      Consensus CDS
      CCDS20440.1
      UniProtKB/Swiss-Prot
      Q3UYG6, Q6P7W5
      Related
      ENSMUSP00000038211.8, ENSMUST00000040234.9
      Conserved Domains (3) summary
      COG1676
      Location:292 → 420
      SEN2; tRNA splicing endonuclease [Translation, ribosomal structure and biogenesis]
      pfam01974
      Location:334 → 417
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
      pfam02778
      Location:278 → 324
      tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      115521652..115555297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P7W5.1 GenPept UniProtKB/Swiss-Prot:Q6P7W5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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