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    Fuca alpha-L-fucosidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772574, updated on 29-Dec-2023

    Summary

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    Official Symbol
    Fucaprovided by FlyBase
    Official Full Name
    alpha-L-fucosidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285958
    Locus tag
    Dmel_CG6128
    See related
    AllianceGenome:FB:FBgn0285958
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    a-FUC; alpha-FUC; CG33047; CG6128; Dmel\CG6128; DmFuca; fuc; Fuc; Fuca_Dm
    Summary
    Enables fucose binding activity. Involved in binding activity of sperm to zona pellucida and defense response to bacterium. Located in outer acrosomal membrane and sperm plasma membrane. Is expressed in several structures, including adult and reproductive system. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to several human genes including FUCA2 (alpha-L-fucosidase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    68C12-68C12; 3-36 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11518798..11522713, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11511898..11513924, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Salivary gland secretion 3 Neighboring gene uncharacterized protein Neighboring gene Mob2 Neighboring gene mir-4968 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila sperm surface alpha-L-fucosidase interacts with the egg coats through its core fucose residues. Intra J, et al. Insect Biochem Mol Biol, 2015 Aug. PMID 26101846
    2. Recombinant expression of Drosophila melanogaster α-L-fucosidase in Trichoplusia ni cells. Xu Y, et al. J Insect Physiol, 2011 Sep. PMID 21708168
    3. Comparative and phylogenetic analysis of alpha-L-fucosidase genes. Intra J, et al. Gene, 2007 May 1. PMID 17175120
    4. An alpha-L-fucosidase potentially involved in fertilization is present on Drosophila spermatozoa surface. Intra J, et al. Mol Reprod Dev, 2006 Sep. PMID 16736526
    5. Interspecific analysis of the glycosidases of the sperm plasma membrane in Drosophila. Intra J, et al. Mol Reprod Dev, 2009 Jan. PMID 18484570

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-L-fucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-L-fucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-L-fucosidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables fucose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosaminoglycan catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in glycoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-L-fucosidase
    Names
    CG6128-PB
    CG6128-PC
    Fuca-PB
    Fuca-PC
    alpha fucosidase
    alpha-fucosidase
    NP_001303363.1
    NP_648472.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11518798..11522713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316434.1 → NP_001303363.1  alpha-L-fucosidase, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1U8, Q9VTJ4
      Conserved Domains (3) summary
      smart00812
      Location:28 → 409
      Alpha_L_fucos; Alpha-L-fucosidase
      COG3669
      Location:60 → 373
      AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]
      pfam16757
      Location:376 → 492
      Fucosidase_C; Alpha-L-fucosidase C-terminal domain

    2. NM_140215.3 → NP_648472.1  alpha-L-fucosidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648472.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1U8, Q9VTJ4
      Conserved Domains (3) summary
      smart00812
      Location:28 → 409
      Alpha_L_fucos; Alpha-L-fucosidase
      COG3669
      Location:60 → 373
      AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]
      pfam16757
      Location:376 → 492
      Fucosidase_C; Alpha-L-fucosidase C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTJ4.2 Q9VTJ4

    Gene LinkOut

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