U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ACVR2B activin A receptor type 2B [ Gallus gallus (chicken) ]

    Gene ID: 374213, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Symbol
    ACVR2Bprovided by CGNC
    Full Name
    activin A receptor type 2Bprovided by CGNC
    Primary source
    CGNC:4620
    See related
    Ensembl:ENSGALG00010027103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ActRIIB; ACTR-IIB
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (5716617..5842556, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (5721740..5841353, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene voltage-gated sodium channel SNS Neighboring gene sodium voltage-gated channel alpha subunit 5 Neighboring gene exo/endonuclease G Neighboring gene uncharacterized LOC124417733 Neighboring gene microRNA 6600 Neighboring gene uncharacterized LOC121109581 Neighboring gene xylulokinase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular characterization and computational structure prediction of activin receptor type IIB in aseel and broiler chicken. Vishnu PG, et al. Res Vet Sci, 2019 Oct. PMID 31491670
    2. Signaling via the transcriptionally regulated activin receptor 2B is a novel mediator of neuronal cell death during chicken ciliary ganglion development. Koszinowski S, et al. Int J Dev Neurosci, 2015 Apr. PMID 25660516
    3. Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary. Lovell TM, et al. J Endocrinol, 2006 Feb. PMID 16461550
    4. Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle. Lovell TM, et al. J Endocrinol, 2005 Sep. PMID 16135664
    5. The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube. Timmer J, et al. Dev Biol, 2005 Sep 1. PMID 16039645

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken.
      Title: Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken.
    2. and formed a sub cluster with in avian cluster. The current research provides insights about structural and functional aspects of the receptor and also aids in understanding the evolutionary history of ACTRIIB.
      Title: Molecular characterization and computational structure prediction of activin receptor type IIB in aseel and broiler chicken.
    3. This study demonstrated that the role of ACVR2B expression in ciliary ganglion neuronal development, investigating its function in neuronal differentiation and ontogenetic cell death.
      Title: Signaling via the transcriptionally regulated activin receptor 2B is a novel mediator of neuronal cell death during chicken ciliary ganglion development.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables activin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables activin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of activin receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    activin receptor type-2B
    Names
    activin A receptor, type IIB
    activin receptor type 2B
    activin receptor type IIB
    NP_989648.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204317.2 → NP_989648.1  activin receptor type-2B precursor

      See identical proteins and their annotated locations for NP_989648.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000035
      UniProtKB/Swiss-Prot
      Q90670
      UniProtKB/TrEMBL
      A0A1Z1XG81, A0A1Z1XG83
      Related
      ENSGALP00010039953.1, ENSGALT00010065687.1
      Conserved Domains (3) summary
      smart00220
      Location:198 → 471
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14140
      Location:194 → 484
      STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
      pfam01064
      Location:39 → 117
      Activin_recp; Activin types I and II receptor domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      5716617..5842556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      5721740..5841353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90670.1 GenPept UniProtKB/Swiss-Prot:Q90670

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous