INCENP inner centromere protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: INCENPprovided by HGNC
Official Full Name: inner centromere proteinprovided by HGNC
Primary source: HGNC:HGNC:6058
See related: Ensembl:ENSG00000149503 MIM:604411; AllianceGenome:HGNC:6058
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 6.2), esophagus (RPKM 5.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (62124011..62153169)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (62113566..62142731)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (61891483..61920641)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer.
Title: High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer.
Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.
Title: Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.
An ATM-Chk2-INCENP pathway activates the abscission checkpoint.
Title: An ATM-Chk2-INCENP pathway activates the abscission checkpoint.
lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR-1301-3p/INCENP axis and interacting with SOX2.
Title: lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR-1301-3p/INCENP axis and interacting with SOX2.
Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions.
Title: Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions.
Dysregulation of INCENP contributes to neuroblastoma tumorigenesis
Title: Targeting the Chromosomal Passenger Complex Subunit INCENP Induces Polyploidization, Apoptosis, and Senescence in Neuroblastoma.
In this study, we designed and synthesized 7-19 residues of inner centromere protein (INCENP)-derived small peptides (INC peptides) as novel survivin-targeting agents.
Title: Discovery of inner centromere protein-derived small peptides for cancer imaging and treatment targeting survivin.
Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin and Inner Centromere Protein (INCENP) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported.
Title: Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex.
Data unveils a novel mechanism of PRMT1-mediated CPC regulation through methylation of INCENP.
Title: PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.
The data suggest that INCENP in the chromosomal passenger complex pathway contributes to estrogen receptor-negative breast cancer susceptibility in the European population.
Title: Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr upregulates INCENP in HeLa cells within 12 hours of exposure	PubMed
	vpr	HIV-1 Vpr interferes with the heterochromatin structure by displacing HP1-alpha and HP1-gamma proteins in interphase, which leads to relocalization of the centromere chromatin proteins Mis12, Sgo1, and INCENP/CPC after prophase	PubMed
	vpr	AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

INCENP__6466 (e-PCR)
- UniSTS:464498

MARC_3953-3954:996679214:1 (e-PCR)
- UniSTS:269294

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular function activator activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic spindle assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic spindle midzone assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic sister chromatid separation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in central element	IEA Inferred from Electronic Annotation more info
located_in chromocenter	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	IEA Inferred from Electronic Annotation more info
is_active_in meiotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inner centromere protein

Names: binds and activates aurora-B and -C in vivo and in vitro; chromosomal passenger protein; inner centromere protein INCENP; inner centromere protein antigens 135/155kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040694.2 → NP_001035784.1 inner centromere protein isoform 1

See identical proteins and their annotated locations for NP_001035784.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AP002793, AW839685, BC098576, BC111732, CV569756

Consensus CDS

CCDS44624.1

UniProtKB/Swiss-Prot

A8MQD2, Q5Y192, Q9NQS7

Related

ENSP00000378295.3, ENST00000394818.8

Conserved Domains (2) summary

pfam03941
Location:831 → 882

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
NM_020238.3 → NP_064623.2 inner centromere protein isoform 2

See identical proteins and their annotated locations for NP_064623.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AP002793, AW839685, BC032678, BC098576, BC111732, CV569756

Consensus CDS

CCDS31582.1

UniProtKB/Swiss-Prot

Q9NQS7

Related

ENSP00000278849.4, ENST00000278849.4

Conserved Domains (3) summary

pfam03941
Location:827 → 878

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

cl00583
Location:520 → 613

PhaG_MnhG_YufB; Na+/H+ antiporter subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

62124011..62153169

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011544995.4 → XP_011543297.1 inner centromere protein isoform X1

Conserved Domains (2) summary

pfam03941
Location:846 → 897

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
XM_006718533.4 → XP_006718596.1 inner centromere protein isoform X5

Conserved Domains (2) summary

pfam03941
Location:835 → 886

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
XM_011544996.4 → XP_011543298.1 inner centromere protein isoform X3

Conserved Domains (2) summary

pfam03941
Location:842 → 893

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
XM_011544997.3 → XP_011543299.1 inner centromere protein isoform X2

Conserved Domains (3) summary

pfam03941
Location:842 → 893

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

cl00583
Location:520 → 613

PhaG_MnhG_YufB; Na+/H+ antiporter subunit
XM_047426886.1 → XP_047282842.1 inner centromere protein isoform X6
XM_011544998.4 → XP_011543300.1 inner centromere protein isoform X4

Conserved Domains (3) summary

pfam03941
Location:838 → 889

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

cl00583
Location:520 → 613

PhaG_MnhG_YufB; Na+/H+ antiporter subunit