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    Rnasel ribonuclease L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 359726, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Rnaselprovided by RGD
    Official Full Name
    ribonuclease Lprovided by RGD
    Primary source
    RGD:727933
    See related
    Ensembl:ENSRNOG00000027017 AllianceGenome:RGD:727933
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables rRNA binding activity and ribonuclease activity. Involved in rRNA processing. Located in nuclear matrix. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 67.5), Thymus (RPKM 55.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (68446641..68460804)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65894990..65910354)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (71188712..71202636)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 8 Neighboring gene regulator of G-protein signaling 16 Neighboring gene regulator of G-protein signaling like 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A3-like Neighboring gene regulator of G-protein signaling like 2 homolog (mouse) Neighboring gene glutamate-ammonia ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer. Downing SR, et al. Clin Prostate Cancer, 2003 Dec. PMID 15040862
    2. Evidence for age-dependent impairment of antiviral 2',5'-oligoadenylate synthetase/ribonuclease L-system in tissues of rat. Pfeifer K, et al. Mech Ageing Dev, 1993 Feb. PMID 8469023
    3. Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L. Goldstein SA, et al. J Virol, 2017 Mar 1. PMID 28003490, Free PMC Article
    4. Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Han Y, et al. Science, 2014 Mar 14. PMID 24578532, Free PMC Article
    5. Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling. Zhou Y, et al. J Immunol, 2013 Sep 1. PMID 23913960, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-5A-dependent ribonuclease
    Names
    ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
    ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent)
    NP_872614.1
    XP_006250061.1
    XP_006250066.1
    XP_038946795.1
    XP_038946796.1
    XP_038946797.1
    XP_038946798.1
    XP_038946799.1
    XP_038946800.1
    XP_038946801.1
    XP_038946802.1
    XP_063128491.1
    XP_063128493.1
    XP_063128494.1
    XP_063128495.1
    XP_063128496.1
    XP_063128497.1
    XP_063128498.1
    XP_063128499.1
    XP_063128500.1
    XP_063128501.1
    XP_063128502.1
    XP_063128503.1
    XP_063128504.1
    XP_063128505.1
    XP_063128506.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182673.2 → NP_872614.1  2-5A-dependent ribonuclease

      See identical proteins and their annotated locations for NP_872614.1

      Status: PROVISIONAL

      Source sequence(s)
      AY262823
      UniProtKB/TrEMBL
      Q80WM6
      Related
      ENSRNOP00000032975.3, ENSRNOT00000032157.5
      Conserved Domains (7) summary
      cd10423
      Location:593 → 710
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      cd00204
      Location:59 → 188
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00069
      Location:374 → 589
      Pkinase; Protein kinase domain
      pfam12796
      Location:63 → 153
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:28 → 79
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      cl21453
      Location:366 → 590
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      68446641..68460804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090872.2 → XP_038946800.1  2-5A-dependent ribonuclease isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:259 → 369
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:29 → 188
      PHA02875; ankyrin repeat protein; Provisional
      cd10423
      Location:599 → 715
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 216
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:224 → 302
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006250004.5 → XP_006250066.1  2-5A-dependent ribonuclease isoform X3

      Conserved Domains (6) summary
      cd00204
      Location:59 → 188
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00069
      Location:374 → 589
      Pkinase; Protein kinase domain
      pfam12796
      Location:63 → 153
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:28 → 79
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    3. XM_039090873.2 → XP_038946801.1  2-5A-dependent ribonuclease isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:259 → 369
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:29 → 188
      PHA02875; ankyrin repeat protein; Provisional
      cd10423
      Location:599 → 715
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 216
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:224 → 302
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039090874.2 → XP_038946802.1  2-5A-dependent ribonuclease isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:259 → 369
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:29 → 188
      PHA02875; ankyrin repeat protein; Provisional
      cd10423
      Location:599 → 715
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 216
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:224 → 302
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    5. XM_063272421.1 → XP_063128491.1  2-5A-dependent ribonuclease isoform X1

    6. XM_039090867.2 → XP_038946795.1  2-5A-dependent ribonuclease isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:259 → 369
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:29 → 188
      PHA02875; ankyrin repeat protein; Provisional
      cd10423
      Location:599 → 715
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 216
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:224 → 302
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    7. XM_063272423.1 → XP_063128493.1  2-5A-dependent ribonuclease isoform X1

    8. XM_039090870.2 → XP_038946798.1  2-5A-dependent ribonuclease isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:259 → 369
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:29 → 188
      PHA02875; ankyrin repeat protein; Provisional
      cd10423
      Location:599 → 715
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 216
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:224 → 302
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    9. XM_063272436.1 → XP_063128506.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    10. XM_063272434.1 → XP_063128504.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    11. XM_063272435.1 → XP_063128505.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    12. XM_063272426.1 → XP_063128496.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    13. XM_006249999.5 → XP_006250061.1  2-5A-dependent ribonuclease isoform X2

      See identical proteins and their annotated locations for XP_006250061.1

      UniProtKB/TrEMBL
      A6ICV9, G3V915
      Conserved Domains (7) summary
      PTZ00322
      Location:259 → 369
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:29 → 188
      PHA02875; ankyrin repeat protein; Provisional
      cd10423
      Location:593 → 710
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 216
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:224 → 302
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    14. XM_063272428.1 → XP_063128498.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    15. XM_063272429.1 → XP_063128499.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    16. XM_063272431.1 → XP_063128501.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    17. XM_063272425.1 → XP_063128495.1  2-5A-dependent ribonuclease isoform X1

    18. XM_039090868.2 → XP_038946796.1  2-5A-dependent ribonuclease isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:259 → 369
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:29 → 188
      PHA02875; ankyrin repeat protein; Provisional
      cd10423
      Location:599 → 715
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 216
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:224 → 302
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    19. XM_063272424.1 → XP_063128494.1  2-5A-dependent ribonuclease isoform X1

    20. XM_063272427.1 → XP_063128497.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    21. XM_063272432.1 → XP_063128502.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    22. XM_039090871.1 → XP_038946799.1  2-5A-dependent ribonuclease isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:259 → 369
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:29 → 188
      PHA02875; ankyrin repeat protein; Provisional
      cd10423
      Location:599 → 715
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 216
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:224 → 302
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    23. XM_063272433.1 → XP_063128503.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915

    24. XM_039090869.2 → XP_038946797.1  2-5A-dependent ribonuclease isoform X1

      Conserved Domains (7) summary
      PTZ00322
      Location:259 → 369
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:29 → 188
      PHA02875; ankyrin repeat protein; Provisional
      cd10423
      Location:599 → 715
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 216
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:224 → 302
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:379 → 590
      PKc_like; Protein Kinases, catalytic domain

    25. XM_063272430.1 → XP_063128500.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      A6ICV9, G3V915
    Nucleotide Protein Strain
    Heading Accession and Version

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