alox5ap arachidonate 5-lipoxygenase-activating protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: alox5approvided by ZNC
Official Full Name: arachidonate 5-lipoxygenase-activating proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9322
See related: Ensembl:ENSDARG00000054755 AllianceGenome:ZFIN:ZDB-GENE-030131-9322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63982; wu:fj65d02
Summary: Predicted to enable glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Acts upstream of or within angiogenesis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma; brain infarction (multiple); breast cancer; and cerebral palsy. Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (36458576..36463837)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (36514818..36520079)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene-C4 synthase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukotriene biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukotriene metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arachidonate 5-lipoxygenase-activating protein

Names: Flap

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200061.2 → NP_956355.2 arachidonate 5-lipoxygenase-activating protein precursor

Status: VALIDATED

Source sequence(s)

BX548163, EB943618

UniProtKB/TrEMBL

A0A8M1PDY6, F1QKS8

Related

ENSDARP00000071476.5, ENSDART00000077008.7

Conserved Domains (1) summary

pfam01124
Location:37 → 122

MAPEG; MAPEG family