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    usp24 ubiquitin specific peptidase 24 [ Danio rerio (zebrafish) ]

    Gene ID: 325631, updated on 11-Apr-2024

    Summary

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    Official Symbol
    usp24provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 24provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4356
    See related
    Ensembl:ENSDARG00000059925 AllianceGenome:ZFIN:ZDB-GENE-030131-4356
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc94c01; wu:fm69d03; si:ch211-257m21.2
    Summary
    Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Acts upstream of or within central nervous system morphogenesis and cranial skeletal system development. Predicted to be active in cytosol and nucleus. Orthologous to human USP24 (ubiquitin specific peptidase 24). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (7442722..7583964, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (7452707..7595332, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene zmp:0000001074 Neighboring gene proprotein convertase subtilisin/kexin type 9 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2 Neighboring gene uncharacterized LOC103909293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Role of zebrafish ClC-K/barttin channels in apical kidney chloride reabsorption. Pérez-Rius C, et al. J Physiol, 2019 Aug. PMID 31177533
    2. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
    3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 24
    XP_002665714.3
    XP_005170208.1
    XP_009292847.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      7442722..7583964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294572.3 → XP_009292847.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ALC7
      Conserved Domains (3) summary
      cd02659
      Location:1691 → 2048
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14286
      Location:7 → 43
      UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      pfam00443
      Location:1693 → 2043
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_002665668.6 → XP_002665714.3  ubiquitin carboxyl-terminal hydrolase 24 isoform X3

      UniProtKB/TrEMBL
      A0A8M1RKY0
      Conserved Domains (3) summary
      cd02659
      Location:1659 → 2016
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14286
      Location:7 → 43
      UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      pfam00443
      Location:1661 → 2011
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_005170151.4 → XP_005170208.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHH2, F1Q6K1
      Related
      ENSDARP00000078325.5, ENSDART00000083890.6
      Conserved Domains (3) summary
      cd02659
      Location:1691 → 2048
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14286
      Location:7 → 43
      UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      pfam00443
      Location:1693 → 2043
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein Strain
    Heading Accession and Version

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