Gapdh2 Glyceraldehyde 3 phosphate dehydrogenase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gapdh2provided by FlyBase
Official Full Name: Glyceraldehyde 3 phosphate dehydrogenase 2provided by FlyBase
Primary source: FLYBASE:FBgn0001092
Locus tag: Dmel_CG8893
See related: AllianceGenome:FB:FBgn0001092
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8893; Dmel\CG8893; dmGAPDH; GA3PDH; GADPH; GAP; Gapd; gapdh; Gapdh; GAPDH; GAPDH II; Gapdh-2; Gapdh13F; gapdh2; GAPDH2
Summary: Enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Involved in glucose homeostasis and glycolytic process. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including GAPDH (glyceraldehyde-3-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15868145..15869661)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15762178..15763694)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables peptidyl-cysteine S-nitrosylase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

Names: CG8893-PA; CG8893-PC; G3-P dehydrogenase; GAPDH2; Gapdh2-PA; Gapdh2-PC; dehydrogenase; glyceraldehyde 3-phosphate dehydrogenase; glyceraldehyde-3-phosphate; glyceraldehyde-3-phosphate dehydrogenase

NP_001259584.1

NP_542445.1

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The following sections contain reference sequences that belong to a specific genome build. Explain