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    alox12 arachidonate 12-lipoxygenase [ Danio rerio (zebrafish) ]

    Gene ID: 322732, updated on 11-Apr-2024

    Summary

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    Official Symbol
    alox12provided by ZNC
    Official Full Name
    arachidonate 12-lipoxygenaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1452
    See related
    Ensembl:ENSDARG00000069463 AllianceGenome:ZFIN:ZDB-GENE-030131-1452
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64120; wu:fb72a11
    Summary
    Enables arachidonate 12(S)-lipoxygenase activity and calcium ion binding activity. Predicted to be involved in fatty acid metabolic process and lipid oxidation. Located in nucleus. Is expressed in several structures, including EVL; digestive system; epidermal cell; epidermis; and periderm. Orthologous to several human genes including ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (26029733..26047946)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (25758540..25776753)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene arrestin, beta 2b Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene si:dkey-6n21.12 Neighboring gene ribonuclease, RNase K a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase. Mittal M, et al. Biochim Biophys Acta Gen Subj, 2017 Aug. PMID 28528958
    2. Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development. Haas U, et al. Proc Natl Acad Sci U S A, 2011 Dec 20. PMID 22143766, Free PMC Article
    3. PGE(2) production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo. Loynes CA, et al. Sci Adv, 2018 Sep. PMID 30191175, Free PMC Article
    4. Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept. Jansen C, et al. J Biol Chem, 2011 Oct 28. PMID 21880725, Free PMC Article
    5. Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. Katikaneni A, et al. Nat Cell Biol, 2020 Sep. PMID 32868902, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
      Title: 12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
    2. A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.
      Title: A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables arachidonate 12(S)-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate 12(S)-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arachidonate 12(S)-lipoxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate 12(S)-lipoxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables arachidonate 15-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables linoleate 13S-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipoxygenase pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arachidonate 12-lipoxygenase, 12S-type
    Names
    ALOX1
    LOX1
    NP_955912.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199618.1 → NP_955912.1  arachidonate 12-lipoxygenase, 12S-type

      See identical proteins and their annotated locations for NP_955912.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054621
      UniProtKB/TrEMBL
      A0A8M1P9T6, Q7T2A9
      Related
      ENSDARP00000091900.3, ENSDART00000101126.5
      Conserved Domains (2) summary
      cd01753
      Location:1 → 115
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:227 → 649
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      26029733..26047946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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