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    ckmt1 creatine kinase, mitochondrial 1 [ Danio rerio (zebrafish) ]

    Gene ID: 321892, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ckmt1provided by ZNC
    Official Full Name
    creatine kinase, mitochondrial 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-611
    See related
    Ensembl:ENSDARG00000016598 AllianceGenome:ZFIN:ZDB-GENE-030131-611
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb37h03; fb69a12; wu:fb37h03; wu:fb69a12
    Summary
    Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in central nervous system; cranial ganglion; pleuroperitoneal region; retinal neural layer; and yolk syncytial layer. Orthologous to several human genes including CKMT1A (creatine kinase, mitochondrial 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 25
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (21830019..21847557)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (21732471..21750005)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3Ab Neighboring gene adenosylhomocysteinase like 2a Neighboring gene F-box protein 31 Neighboring gene dynein light chain roadblock-type 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comprehensive transcriptome analysis reveal key molecular events in the pearl oyster after pre-grafting conditioning. Jiao Y, et al. Fish Shellfish Immunol, 2019 Sep. PMID 31195116
    2. The Zebrafish Equivalent of Alzheimer's Disease-Associated PRESENILIN Isoform PS2V Regulates Inflammatory and Other Responses to Hypoxic Stress. Ebrahimie E, et al. J Alzheimers Dis, 2016 Mar 31. PMID 27031468
    3. Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas. Zhang Y, et al. Gene Expr Patterns, 2013 Jun-Jul. PMID 23557786
    4. High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish. Ma Q, et al. Fish Physiol Biochem, 2020 Apr. PMID 31820205
    5. Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Ahi EP, et al. Fish Physiol Biochem, 2021 Aug. PMID 34236575, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables creatine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables creatine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphocreatine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphocreatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    creatine kinase U-type, mitochondrial; creatine kinase, mitochondrial 1
    NP_942096.1
    XP_021326125.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198801.1 → NP_942096.1  creatine kinase, mitochondrial 1

      See identical proteins and their annotated locations for NP_942096.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048050
      UniProtKB/TrEMBL
      A0A2R8PZ48, B2GSL6, Q7ZUN7
      Related
      ENSDARP00000011271.6, ENSDART00000027393.8
      Conserved Domains (1) summary
      cd00716
      Location:50 → 407
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      21830019..21847557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470450.1 → XP_021326125.1  creatine kinase U-type, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A2R8PZ48, B2GSL6, Q7ZUN7
      Related
      ENSDARP00000154305.1, ENSDART00000187606.1
      Conserved Domains (1) summary
      cd00716
      Location:50 → 407
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395202.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      85838..106448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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