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    Cyb5r2 cytochrome b5 reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 320635, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cyb5r2provided by MGI
    Official Full Name
    cytochrome b5 reductase 2provided by MGI
    Primary source
    MGI:MGI:2444415
    See related
    Ensembl:ENSMUSG00000048065 AllianceGenome:MGI:2444415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b5R.2; D630003K02Rik
    Summary
    Predicted to enable FAD binding activity and cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to act upstream of or within sterol biosynthetic process. Located in mitochondrion. Orthologous to human CYB5R2 (cytochrome b5 reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 2.5), genital fat pad adult (RPKM 1.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E3; 7 57.21 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (107347653..107357407, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (107748446..107758202, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin IX Neighboring gene STARR-seq mESC enhancer starr_19764 Neighboring gene STARR-positive B cell enhancer ABC_E8198 Neighboring gene olfactomedin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1352 Neighboring gene STARR-seq mESC enhancer starr_19765 Neighboring gene PTPRF interacting protein, binding protein 2 (liprin beta 2) Neighboring gene STARR-seq mESC enhancer starr_19766 Neighboring gene STARR-positive B cell enhancer mm9_chr7:114807884-114808185 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:114846576-114846777 Neighboring gene STARR-seq mESC enhancer starr_19769 Neighboring gene STARR-seq mESC enhancer starr_19770 Neighboring gene ovochymase 2 Neighboring gene olfactory receptor family 5 subfamily P member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial diaphorases as NAD⁺ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition. Kiss G, et al. FASEB J, 2014 Apr. PMID 24391134, Free PMC Article
    2. ¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models. Probert F, et al. J Proteome Res, 2015 May 1. PMID 25849460
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130177, MGC130178

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-b5 reductase activity, acting on NAD(P)H ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADH-cytochrome b5 reductase 2
    Names
    cytochrome b5 reductase b5R.2
    NP_001192156.1
    NP_796190.1
    XP_006508011.1
    XP_017177792.1
    XP_017177793.1
    XP_017177794.1
    XP_030098539.1
    XP_036009061.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205227.1 → NP_001192156.1  NADH-cytochrome b5 reductase 2 isoform 1

      See identical proteins and their annotated locations for NP_001192156.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK147952, AL513346
      Consensus CDS
      CCDS57579.1
      UniProtKB/Swiss-Prot
      Q3KNK3
      Related
      ENSMUSP00000050061.8, ENSMUST00000052438.8
      Conserved Domains (2) summary
      cd06183
      Location:20 → 292
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      PTZ00319
      Location:13 → 292
      PTZ00319; NADH-cytochrome B5 reductase; Provisional

    2. NM_177216.4 → NP_796190.1  NADH-cytochrome b5 reductase 2 isoform 2

      See identical proteins and their annotated locations for NP_796190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK085272, AK147952, AL513346
      Consensus CDS
      CCDS85373.1
      UniProtKB/Swiss-Prot
      Q3KNK3, Q3UGG1, Q8BUG7
      Related
      ENSMUSP00000146504.2, ENSMUST00000208217.2
      Conserved Domains (1) summary
      PLN02252
      Location:13 → 276
      PLN02252; nitrate reductase [NADPH]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      107347653..107357407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322303.3 → XP_017177792.1  NADH-cytochrome b5 reductase 2 isoform X1

      Conserved Domains (1) summary
      PLN02252
      Location:25 → 271
      PLN02252; nitrate reductase [NADPH]

    2. XM_036153168.1 → XP_036009061.1  NADH-cytochrome b5 reductase 2 isoform X4

      Conserved Domains (1) summary
      PLN02252
      Location:13 → 220
      PLN02252; nitrate reductase [NADPH]

    3. XM_006507948.5 → XP_006508011.1  NADH-cytochrome b5 reductase 2 isoform X2

      Conserved Domains (1) summary
      PLN02252
      Location:25 → 299
      PLN02252; nitrate reductase [NADPH]

    4. XM_017322304.3 → XP_017177793.1  NADH-cytochrome b5 reductase 2 isoform X3

      UniProtKB/Swiss-Prot
      Q3KNK3, Q3UGG1, Q8BUG7
      Conserved Domains (1) summary
      PLN02252
      Location:13 → 276
      PLN02252; nitrate reductase [NADPH]

    5. XM_030242679.2 → XP_030098539.1  NADH-cytochrome b5 reductase 2 isoform X5

      Conserved Domains (1) summary
      cd06183
      Location:1 → 175
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

    6. XM_017322305.3 → XP_017177794.1  NADH-cytochrome b5 reductase 2 isoform X3

      UniProtKB/Swiss-Prot
      Q3KNK3, Q3UGG1, Q8BUG7
      Conserved Domains (1) summary
      PLN02252
      Location:13 → 276
      PLN02252; nitrate reductase [NADPH]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KNK3.2 GenPept UniProtKB/Swiss-Prot:Q3KNK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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