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    HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase [ Bos taurus (cattle) ]

    Gene ID: 317658, updated on 13-Apr-2024

    Summary

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    Official Symbol
    HMGCLprovided by VGNC
    Official Full Name
    3-hydroxy-3-methylglutaryl-CoA lyaseprovided by VGNC
    Primary source
    VGNC:VGNC:29877
    See related
    BGD:BT16088; Ensembl:ENSBTAG00000021832
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (129091585..129109718)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene cannabinoid receptor 2 Neighboring gene alpha-L-fucosidase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132343455 Neighboring gene UDP-galactose-4-epimerase Neighboring gene lysophospholipase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hydroxymethylglutaryl-CoA lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-leucine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ketone body biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxymethylglutaryl-CoA lyase, mitochondrial
    Names
    3-hydroxy-3-methylglutarate-CoA lyase
    3-hydroxymethyl-3-methylglutaryl-CoA lyase
    3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
    HL
    HMG-CoA lyase
    hydroxymethylglutaricaciduria
    NP_001068600.1
    XP_059747855.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075132.1 → NP_001068600.1  hydroxymethylglutaryl-CoA lyase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001068600.1

      Status: PROVISIONAL

      Source sequence(s)
      BC118276
      UniProtKB/Swiss-Prot
      Q148J2, Q29448
      Related
      ENSBTAP00000029103.3, ENSBTAT00000029103.5
      Conserved Domains (1) summary
      cd07938
      Location:35 → 308
      DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      129091585..129109718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891872.1 → XP_059747855.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29448.2 GenPept UniProtKB/Swiss-Prot:Q29448

    Gene LinkOut

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