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    Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314312, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Entpd5provided by RGD
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 5provided by RGD
    Primary source
    RGD:735219
    See related
    Ensembl:ENSRNOG00000033206 AllianceGenome:RGD:735219
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcph
    Summary
    Predicted to enable guanosine-diphosphatase activity and uridine-diphosphatase activity. Predicted to be involved in several processes, including positive regulation of glycolytic process; protein N-linked glycosylation; and regulation of phosphatidylinositol 3-kinase signaling. Located in endoplasmic reticulum lumen. Orthologous to human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 696.3), Adrenal (RPKM 519.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109750210..109786376, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104019095..104055311, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108087677..108123811, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene coenzyme Q6 monooxygenase Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase 6 family, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene. Solanas M, et al. Mol Carcinog, 2002 Apr. PMID 11933075
    2. Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism. Baldissarelli J, et al. Biomed Pharmacother, 2016 Dec. PMID 27832996
    3. Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase. Murphy-Piedmonte DM, et al. Biochim Biophys Acta, 2005 Mar 14. PMID 15698960
    4. Biochemical characterization of CD39L4. Mulero JJ, et al. Biochemistry, 2000 Oct 24. PMID 11041857
    5. CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates. Mulero JJ, et al. J Biol Chem, 1999 Jul 16. PMID 10400613

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Quercetin decreases NTPDase, 5'-nucleotidase and adenosine deaminase activities in blood platelets of hypothyroid rats, and improves the oxidative profile to reduce platelet aggregation.
      Title: Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism.
    2. the expression of of PCPH in benign and malignant mammary tumors (PCPH)
      Title: Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ADP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables IDP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect 'de novo' post-translational protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect 'de novo' post-translational protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in UDP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect UDP-glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect UDP-glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleoside diphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 5
    Names
    GDPase ENTPD5
    NTPDase 5
    UDPase ENTPD5
    guanosine-diphosphatase ENTPD5
    uridine-diphosphatase ENTPD5
    NP_955426.2
    XP_006240405.1
    XP_006240406.1
    XP_006240407.1
    XP_006240408.1
    XP_017449640.1
    XP_017449641.1
    XP_017449642.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199394.2 → NP_955426.2  ectonucleoside triphosphate diphosphohydrolase 5 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q6P6S9
      UniProtKB/TrEMBL
      A6JDW3
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      109750210..109786376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240344.3 → XP_006240406.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

      See identical proteins and their annotated locations for XP_006240406.1

      UniProtKB/Swiss-Prot
      Q6P6S9
      UniProtKB/TrEMBL
      A6JDW3
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. XM_017594152.3 → XP_017449641.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWS8, A6JDW0, A6JDW1
      Related
      ENSRNOP00000041026.4
      Conserved Domains (1) summary
      cl17037
      Location:63 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. XM_017594153.3 → XP_017449642.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWS8, A6JDW0, A6JDW1
      Related
      ENSRNOP00000083944.1
      Conserved Domains (1) summary
      cl17037
      Location:63 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. XM_006240345.5 → XP_006240407.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

      See identical proteins and their annotated locations for XP_006240407.1

      UniProtKB/Swiss-Prot
      Q6P6S9
      UniProtKB/TrEMBL
      A6JDW3
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    5. XM_017594151.3 → XP_017449640.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWS8, A6JDW0, A6JDW1
      Conserved Domains (1) summary
      cl17037
      Location:63 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    6. XM_006240343.5 → XP_006240405.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

      See identical proteins and their annotated locations for XP_006240405.1

      UniProtKB/Swiss-Prot
      Q6P6S9
      UniProtKB/TrEMBL
      A6JDW3
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    7. XM_006240346.5 → XP_006240408.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

      See identical proteins and their annotated locations for XP_006240408.1

      UniProtKB/Swiss-Prot
      Q6P6S9
      UniProtKB/TrEMBL
      A6JDW3
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6S9.1 GenPept UniProtKB/Swiss-Prot:Q6P6S9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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