Rasgrp3 RAS guanyl releasing protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rasgrp3provided by RGD
Official Full Name: RAS guanyl releasing protein 3provided by RGD
Primary source: RGD:1304612
See related: Ensembl:ENSRNOG00000032703 AllianceGenome:RGD:1304612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase regulator activity and enzyme binding activity. Predicted to act upstream of or within Ras protein signal transduction and regulation of GTPase activity. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of guanyl-nucleotide exchange factor complex. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 171.3), Lung (RPKM 121.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12-q13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (25647386..25745952, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (19895361..19993945, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (21072634..21171619, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together these data demonstrate a novel mechanism in which the balance between stability and plasticity in dendritic spines depends on binding of drebrin to actin filaments in a manner that is regulated by Ras.
Title: Interactions between drebrin and Ras regulate dendritic spine plasticity.
These results indicate that RasGRP3 is implicated in phorbol ester-induced, PKC-independent exocytosis.
Title: RasGRP3 mediates phorbol ester-induced, protein kinase C-independent exocytosis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133889 (e-PCR)
- UniSTS:217172

Rasgrp3 (e-PCR), detects polymorphism
- UniSTS:508521

D6Rat43 (e-PCR)
- UniSTS:118976

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of guanyl-nucleotide exchange factor complex	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras guanyl-releasing protein 3

Names: RAS guanyl releasing protein 3 (calcium and DAG-regulated)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399544.1 → NP_001386473.1 ras guanyl-releasing protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2KAU4

Related

ENSRNOP00000075529.1, ENSRNOT00000079819.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

25647386..25745952 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261852.1 → XP_063117922.1 ras guanyl-releasing protein 3 isoform X1
XM_063261857.1 → XP_063117927.1 ras guanyl-releasing protein 3 isoform X1
XM_063261858.1 → XP_063117928.1 ras guanyl-releasing protein 3 isoform X1
XM_063261853.1 → XP_063117923.1 ras guanyl-releasing protein 3 isoform X1
XM_063261856.1 → XP_063117926.1 ras guanyl-releasing protein 3 isoform X1
XM_063261859.1 → XP_063117929.1 ras guanyl-releasing protein 3 isoform X1
XM_063261854.1 → XP_063117924.1 ras guanyl-releasing protein 3 isoform X1
XM_063261855.1 → XP_063117925.1 ras guanyl-releasing protein 3 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108009.2: Suppressed sequence

Description

NM_001108009.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.