Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamts9provided by RGD
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 9provided by RGD
Primary source: RGD:1306889
See related: Ensembl:ENSRNOG00000023257 AllianceGenome:RGD:1306889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including circulatory system development; negative regulation of endothelial cell migration; and negative regulation of sprouting angiogenesis. Predicted to act upstream of or within positive regulation of melanocyte differentiation; proteolysis; and response to bacterium. Predicted to be located in cell surface; endoplasmic reticulum; and extracellular space. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Expression: Biased expression in Adrenal (RPKM 107.5), Lung (RPKM 85.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (126847726..127019924, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (125290633..125462988, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (124660254..124860997, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study indicates that ADAMTS-9 expression is modulated in response to cerebral ischaemia in vivo
Title: ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat.

Submit: New GeneRIF Correction

General gene information

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Markers

BE106470 (e-PCR)
- UniSTS:246276

RH136577 (e-PCR)
- UniSTS:210557

BE199318 (e-PCR)
- UniSTS:207999

AW743315 (e-PCR)
- UniSTS:208000

BF387413 (e-PCR)
- UniSTS:244353

RH137206 (e-PCR)
- UniSTS:219294

BF409636 (e-PCR)
- UniSTS:248992

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aorta morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cornea development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in heart valve morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of developmental pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 9

Names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429136.1 → NP_001416065.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

126847726..127019924 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286081.1 → XP_063142151.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X4
XM_063286077.1 → XP_063142147.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X1
XM_063286078.1 → XP_063142148.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2
XM_063286080.1 → XP_063142150.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X3

RNA

XR_010065646.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107877.1: Suppressed sequence

Description

NM_001107877.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.