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    Vwa7 von Willebrand factor A domain containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309611, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Vwa7provided by RGD
    Official Full Name
    von Willebrand factor A domain containing 7provided by RGD
    Primary source
    RGD:1303137
    See related
    Ensembl:ENSRNOG00000000860 AllianceGenome:RGD:1303137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G7c; NG37; C6orf27
    Summary
    Predicted to be located in extracellular region. Orthologous to human VWA7 (von Willebrand factor A domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 102.0), Muscle (RPKM 41.8) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vwa7 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3799646..3810289, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3794991..3805646, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5008508..5019040)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 1 Neighboring gene U6 spliceosomal RNA Neighboring gene mutS homolog 5 Neighboring gene suppressor APC domain containing 1 Neighboring gene valyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC108349032

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. G7c, a novel gene in the mouse and human major histocompatibility complex class III region, possibly controlling lung tumor susceptibility. Snoek M, et al. Immunogenetics, 2000 Apr. PMID 10803853
    2. Molecular analysis of the major MHC recombinational hot spot located within the G7c gene of the murine class III region that is involved in disease susceptibility. Snoek M, et al. J Immunol, 1998 Jan 1. PMID 9551980
    3. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor A domain-containing protein 7
    Names
    protein G7c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212499.2 → NP_997664.1  von Willebrand factor A domain-containing protein 7 precursor

      See identical proteins and their annotated locations for NP_997664.1

      Status: VALIDATED

      Source sequence(s)
      BX883045
      UniProtKB/Swiss-Prot
      Q6MG64
      UniProtKB/TrEMBL
      A6KTQ7
      Related
      ENSRNOP00000001153.2, ENSRNOT00000001153.5
      Conserved Domains (2) summary
      pfam07217
      Location:163 → 190
      Het-C; Heterokaryon incompatibility protein Het-C
      cl00057
      Location:318 → 496
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3799646..3810289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098675.2 → XP_038954603.1  von Willebrand factor A domain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      A6KTQ7
      Conserved Domains (2) summary
      pfam07217
      Location:163 → 190
      Het-C; Heterokaryon incompatibility protein Het-C
      cl00057
      Location:316 → 422
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_039098674.2 → XP_038954602.1  von Willebrand factor A domain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      A6KTQ7
      Conserved Domains (2) summary
      pfam07217
      Location:163 → 190
      Het-C; Heterokaryon incompatibility protein Het-C
      cl00057
      Location:316 → 422
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. XM_063279117.1 → XP_063135187.1  von Willebrand factor A domain-containing protein 7 isoform X1

    4. XM_063279118.1 → XP_063135188.1  von Willebrand factor A domain-containing protein 7 isoform X2

    RNA

    1. XR_010060676.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MG64.1 GenPept UniProtKB/Swiss-Prot:Q6MG64

    Gene LinkOut

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