U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Kifc3 kinesin family member C3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307644, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Kifc3provided by RGD
    Official Full Name
    kinesin family member C3provided by RGD
    Primary source
    RGD:1307693
    See related
    Ensembl:ENSRNOG00000014087 AllianceGenome:RGD:1307693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    KRP4
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in epithelial cell-cell adhesion and zonula adherens maintenance. Predicted to act upstream of or within Golgi organization and microtubule-based process. Predicted to be located in Golgi apparatus; centrosome; and zonula adherens. Predicted to be part of kinesin complex. Orthologous to human KIFC3 (kinesin family member C3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 88.0), Adrenal (RPKM 44.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    19p13
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9831159..9926405)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9825114..9920371)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10305405..10339186)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 8 Neighboring gene cyclic nucleotide gated channel subunit beta 1 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134483686 Neighboring gene katanin regulatory subunit B1 Neighboring gene dynein regulatory complex subunit 7

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Role of KIFC3 motor protein in Golgi positioning and integration. Xu Y, et al. J Cell Biol, 2002 Jul 22. PMID 12135985, Free PMC Article
    2. Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis. Sperry AO, et al. Mol Biol Cell, 1996 Feb. PMID 8688559, Free PMC Article
    3. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Meng W, et al. Cell, 2008 Nov 28. PMID 19041755
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC156699

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zonula adherens maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in zonula adherens ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    kinesin-like protein KIFC3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103352.1 → NP_001096822.1  kinesin-like protein KIFC3 isoform 2

      See identical proteins and their annotated locations for NP_001096822.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128748
      UniProtKB/TrEMBL
      A0A8I6A4I8, A1A5P4
      Related
      ENSRNOP00000085654.1, ENSRNOT00000093890.1
      Conserved Domains (3) summary
      cd01366
      Location:370 → 697
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00225
      Location:378 → 695
      Kinesin; Kinesin motor domain
      cl12013
      Location:108 → 233
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001401191.1 → NP_001388120.1  kinesin-like protein KIFC3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9831159..9926405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097698.1 → XP_038953626.1  kinesin-like protein KIFC3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADV7
      Conserved Domains (2) summary
      COG1196
      Location:231 → 548
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:598 → 925
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    2. XM_017601265.2 → XP_017456754.2  kinesin-like protein KIFC3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADV7
      Conserved Domains (2) summary
      COG1196
      Location:230 → 547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:597 → 924
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    3. XM_063277982.1 → XP_063134052.1  kinesin-like protein KIFC3 isoform X4

    4. XM_039097699.1 → XP_038953627.1  kinesin-like protein KIFC3 isoform X6

      UniProtKB/TrEMBL
      F7EXA8
      Conserved Domains (2) summary
      TIGR02168
      Location:179 → 488
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:491 → 818
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    5. XM_017601270.2 → XP_017456759.2  kinesin-like protein KIFC3 isoform X7

      UniProtKB/TrEMBL
      F7EXA8
      Conserved Domains (2) summary
      TIGR02168
      Location:179 → 488
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:491 → 818
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    6. XM_017601266.3 → XP_017456755.2  kinesin-like protein KIFC3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADV7
      Conserved Domains (2) summary
      COG1196
      Location:231 → 548
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:598 → 925
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    7. XM_017601269.3 → XP_017456758.2  kinesin-like protein KIFC3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ADV7
      Related
      ENSRNOP00000092397.1
      Conserved Domains (2) summary
      COG1196
      Location:231 → 548
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:598 → 925
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    8. XM_039097701.2 → XP_038953629.1  kinesin-like protein KIFC3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AKJ1
      Conserved Domains (3) summary
      TIGR02168
      Location:93 → 402
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:405 → 732
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam08317
      Location:26 → 150
      Spc7; Spc7 kinetochore protein

    9. XM_039097700.2 → XP_038953628.1  kinesin-like protein KIFC3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AKJ1
      Related
      ENSRNOP00000080196.1
      Conserved Domains (3) summary
      TIGR02168
      Location:93 → 402
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:405 → 732
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam08317
      Location:26 → 150
      Spc7; Spc7 kinetochore protein

    10. XM_063277983.1 → XP_063134053.1  kinesin-like protein KIFC3 isoform X9

    11. XM_008772292.4 → XP_008770514.2  kinesin-like protein KIFC3 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AKJ1
      Conserved Domains (2) summary
      TIGR02168
      Location:58 → 367
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:370 → 697
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    12. XM_008772293.3 → XP_008770515.2  kinesin-like protein KIFC3 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AKJ1
      Related
      ENSRNOP00000094247.1
      Conserved Domains (2) summary
      TIGR02168
      Location:49 → 358
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:361 → 688
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    13. XM_063277984.1 → XP_063134054.1  kinesin-like protein KIFC3 isoform X11

    RNA

    1. XR_005496646.2 RNA Sequence

    2. XR_005496647.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous