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    Srprb SRP receptor subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300965, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Srprbprovided by RGD
    Official Full Name
    SRP receptor subunit betaprovided by RGD
    Primary source
    RGD:1304698
    See related
    AllianceGenome:RGD:1304698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cc1-8; Ab2-417; Ba1-667
    Summary
    Enables ubiquitin protein ligase binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in cytoplasmic microtubule and membrane. Predicted to be part of signal recognition particle receptor complex. Orthologous to human SRPRB (SRP receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 337.8), Kidney (RPKM 250.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112647577..112661524, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103768685..103782632, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111673479..111687426, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 2a1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RAB6B, member RAS oncogene family Neighboring gene uncharacterized LOC134480222 Neighboring gene uncharacterized LOC134480223 Neighboring gene uncharacterized LOC134480224 Neighboring gene transferrin Neighboring gene uncharacterized LOC120094247

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization of APMCF1 and its biological significance of expression pattern in normal and malignant human tissues. Zhang Y, et al. J Exp Clin Cancer Res, 2009 Aug 9. PMID 19664239, Free PMC Article
    2. Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit. Abe K, et al. Biomed Res, 2008 Feb. PMID 18344599
    3. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
    4. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
    5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Tf

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal recognition particle receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle receptor subunit beta
    Names
    SR-beta
    SRP receptor beta subunit
    signal recognition particle receptor, B subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013252.1 → NP_001013270.1  signal recognition particle receptor subunit beta

      See identical proteins and their annotated locations for NP_001013270.1

      Status: VALIDATED

      Source sequence(s)
      BF523222, BF525252, BQ204036
      UniProtKB/Swiss-Prot
      Q4FZX7
      UniProtKB/TrEMBL
      A6I2I7
      Conserved Domains (1) summary
      pfam09439
      Location:60 → 239
      SRPRB; Signal recognition particle receptor beta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      112647577..112661524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZX7.1 GenPept UniProtKB/Swiss-Prot:Q4FZX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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