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    Lonrf3 LON peptidase N-terminal domain and ring finger 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298322, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Lonrf3provided by RGD
    Official Full Name
    LON peptidase N-terminal domain and ring finger 3provided by RGD
    Primary source
    RGD:1565451
    See related
    Ensembl:ENSRNOG00000013092 AllianceGenome:RGD:1565451
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565451
    Summary
    Predicted to enable metal ion binding activity. Orthologous to human LONRF3 (LON peptidase N-terminal domain and ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 112.4), Brain (RPKM 35.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (120430975..120469648)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (115565214..115603886)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (122937987..122973289)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene interleukin 13 receptor subunit alpha 1 Neighboring gene zinc finger CCHC-type containing 12 Neighboring gene U6 spliceosomal RNA Neighboring gene cancer/testis antigen family 47, member B1 Neighboring gene KIAA1210 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LON peptidase N-terminal domain and RING finger protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191585.1 → NP_001178514.1  LON peptidase N-terminal domain and RING finger protein 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6JMF0, D3ZER0
      Related
      ENSRNOP00000017550.3, ENSRNOT00000017550.5
      Conserved Domains (6) summary
      cd00162
      Location:464 → 503
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl19481
      Location:564 → 750
      LON; Found in ATP-dependent protease La (LON)
      sd00006
      Location:248 → 276
      TPR; TPR repeat [structural motif]
      pfam02190
      Location:553 → 754
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
      pfam13414
      Location:247 → 313
      TPR_11; TPR repeat
      cl17238
      Location:163 → 200
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      120430975..120469648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257447.5 → XP_006257509.1  LON peptidase N-terminal domain and RING finger protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K884
      Related
      ENSRNOP00000074508.1
      Conserved Domains (6) summary
      cd00162
      Location:516 → 555
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl19481
      Location:616 → 802
      LON; Found in ATP-dependent protease La (LON)
      sd00006
      Location:248 → 276
      TPR; TPR repeat [structural motif]
      pfam02190
      Location:605 → 806
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
      pfam13414
      Location:247 → 313
      TPR_11; TPR repeat
      cl17238
      Location:163 → 200
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein Strain
    Heading Accession and Version

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