Plin2 perilipin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plin2provided by RGD
Official Full Name: perilipin 2provided by RGD
Primary source: RGD:728889
See related: Ensembl:ENSRNOG00000007060 AllianceGenome:RGD:728889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adfp; Adrp
Summary: Involved in response to organic cyclic compound and response to xenobiotic stimulus. Located in lipid droplet. Orthologous to human PLIN2 (perilipin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 987.2), Adrenal (RPKM 733.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q32

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (106202634..106258748, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (101156648..101211738, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (104984413..105010863, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro.
Title: Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro.
Perilipin 2 downregulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria.
Title: Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria.
New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
Title: New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
Endoplasmic reticulum stress induced by either palmitate, tunicamycin, or thapsigargin led to the degradation of Plin2, an important lipid droplet binding protein.
Title: Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts.
It has been demonstrated that ADRP is critically important during fetal lung maturation as it regulates the alveolar lipid homeostasis.
Title: Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia.
Increased LIF expression after prenatal treatment with ATRA in nitrofen-induced PH suggests that ATRA may have a therapeutic potential in attenuating CDH-associated PH by stimulating alveolar development.
Title: Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia.
This study demonstrates, for the first time, the presence of OXPAT and TIP47 transcripts in rat hepatocytes, as well as their up-regulation with lipid accumulation.
Title: PAT protein mRNA expression in primary rat hepatocytes: Effects of exposure to fatty acids.
Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes.
Title: Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.
In steatotic hepatocytes ADRP selectively stains the surface of macrovesicular and microvesicular lipid droplets.
Title: Adipose differentiation-related protein is a reliable lipid droplet marker in alcoholic fatty liver of rats.
Essential for accumulation of triglycerides in cytosolic lipid droplets. Increase inhibits VLDL. Decrease increases sorting of fatty acids to beta-oxidation and promotes secretion of apoB-48 VLDL1.
Title: Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

RH140452 (e-PCR)
- UniSTS:222527

15.MMHAP53FRE9.seq (e-PCR)
- UniSTS:123263

RH140053 (e-PCR)
- UniSTS:222134

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet disassembly	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid storage	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sequestering of triglyceride	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: perilipin-2

Names: adipose differentiation related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.