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    Ube2q1 ubiquitin conjugating enzyme E2 Q1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295252, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ube2q1provided by RGD
    Official Full Name
    ubiquitin conjugating enzyme E2 Q1provided by RGD
    Primary source
    RGD:1305305
    See related
    Ensembl:ENSRNOG00000020791 AllianceGenome:RGD:1305305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ube2q
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within several processes, including embryo implantation; prolactin secretion; and suckling behavior. Predicted to be active in nucleus. Orthologous to human UBE2Q1 (ubiquitin conjugating enzyme E2 Q1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 184.9), Kidney (RPKM 168.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177496480..177505631)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175198793..175209152)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189106039..189115110)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene adenosine deaminase, RNA-specific Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene uncharacterized LOC103691620 Neighboring gene Src homology 2 domain containing E Neighboring gene interleukin 6 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Downregulation of UBE2Q1 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury. Wan C, et al. J Neurosci Res, 2014 Jan. PMID 24166684
    2. Embryo implantation failure and other reproductive defects in Ube2q1-deficient female mice. Grzmil P, et al. Reproduction, 2013 Jan. PMID 23108111
    3. Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells. Wassler MJ, et al. Stem Cells, 2008 Aug. PMID 18511602
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBE2Q1 might play an important role in the neuropathological process of traumatic brain injury through modulating p53 signaling.
      Title: Downregulation of UBE2Q1 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo implantation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within prolactin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within reproductive system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within suckling behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 Q1
    Names
    ubiquitin-conjugating enzyme E2Q (putative) 1
    ubiquitin-conjugating enzyme E2Q family member 1
    NP_001099918.1
    XP_038957972.1
    XP_063137686.1
    XP_063137687.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106448.2 → NP_001099918.1  ubiquitin-conjugating enzyme E2 Q1

      See identical proteins and their annotated locations for NP_001099918.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166534
      UniProtKB/TrEMBL
      B2GV55, F7FI50
      Related
      ENSRNOP00000028210.5, ENSRNOT00000028210.6
      Conserved Domains (1) summary
      cd00195
      Location:253 → 409
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177496480..177505631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281616.1 → XP_063137686.1  ubiquitin-conjugating enzyme E2 Q1 isoform X1

    2. XM_039102044.2 → XP_038957972.1  ubiquitin-conjugating enzyme E2 Q1 isoform X2

      Conserved Domains (1) summary
      cl00154
      Location:253 → 358
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. XM_063281617.1 → XP_063137687.1  ubiquitin-conjugating enzyme E2 Q1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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