Rpsa ribosomal protein SA [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rpsaprovided by RGD
Official Full Name: ribosomal protein SAprovided by RGD
Primary source: RGD:71026
See related: AllianceGenome:RGD:71026
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lamr1
Summary: Predicted to enable laminin binding activity and ribosome binding activity. Predicted to be a structural constituent of ribosome. Involved in cell-cell adhesion and epithelial cell differentiation. Located in several cellular components, including basement membrane; cytosol; and neuronal cell body. Part of cytosolic small ribosomal subunit. Biomarker of irritable bowel syndrome and sciatic neuropathy. Orthologous to human RPSA (ribosomal protein SA). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 4436.8), Thymus (RPKM 3739.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (128728761..128732736)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (119851225..119855103)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (128806053..128809987)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blockade of 67-kDa Laminin Receptor Facilitates AQP4 Down-Regulation and BBB Disruption via ERK1/2-and p38 MAPK-Mediated PI3K/AKT Activations.
Title: Blockade of 67-kDa Laminin Receptor Facilitates AQP4 Down-Regulation and BBB Disruption via ERK1/2-and p38 MAPK-Mediated PI3K/AKT Activations.
These findings suggested that 67-kDa laminin receptor expression level might be involved in Blood-Brain Barrier integrity in regional specific manners, which might affect the susceptibility to Status Epilepticus induction.
Title: The Regional Specific Alterations in BBB Permeability are Relevant to the Differential Responses of 67-kDa LR Expression in Endothelial Cells and Astrocytes Following Status Epilepticus.
Data indicate that green tea polyphenols (GTPP)-induced potentiation of brain-derived neurotrophic factor (BDNF) action required the cell-surface associated 67 kDa laminin receptor (67LR).
Title: Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide.
involvement of LRP in lesion-induced activation and migration of microglia
Title: Upregulation in rat spinal cord microglia of the nonintegrin laminin receptor 37 kDa-LRP following activation by a traumatic lesion or peripheral injury.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables laminin receptor activity	TAS Traceable Author Statement more info	PubMed
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of small ribosomal subunit	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small ribosomal subunit protein uS2

Names: laminin receptor 1 (67kD, ribosomal protein SA); laminin receptor 1 (ribosomal protein SA)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017138.2 → NP_058834.1 small ribosomal subunit protein uS2

See identical proteins and their annotated locations for NP_058834.1

Status: PROVISIONAL

Source sequence(s)

D25224

UniProtKB/Swiss-Prot

B6ZB78, P38983

UniProtKB/TrEMBL

A6I3Z4

Conserved Domains (1) summary

PTZ00254
Location:1 → 250

PTZ00254; 40S ribosomal protein SA; Provisional