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    Cxxc1 CXXC finger protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291440, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cxxc1provided by RGD
    Official Full Name
    CXXC finger protein 1provided by RGD
    Primary source
    RGD:1310755
    See related
    Ensembl:ENSRNOG00000014614 AllianceGenome:RGD:1310755
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in histone H3-K4 methylation and positive regulation of transcription, DNA-templated. Predicted to be located in cytosol; nuclear matrix; and nuclear speck. Predicted to be part of Set1C/COMPASS complex. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 121.1), Adrenal (RPKM 92.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18q12.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (70088407..70093786)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (67813185..67818556)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (70192520..70197871)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene spindle and kinetochore associated complex subunit 1 Neighboring gene ribosomal protein S17, pseudogene 3 Neighboring gene methyl-CpG binding domain protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension. Cho HM, et al. Am J Hypertens, 2011 Dec. PMID 21814290
    2. Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. Voo KS, et al. Mol Cell Biol, 2000 Mar. PMID 10688657, Free PMC Article
    3. CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals. Lee JH, et al. J Biol Chem, 2002 Nov 1. PMID 12200428
    4. CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse. Tian H, et al. PLoS Genet, 2018 Oct. PMID 30365547, Free PMC Article
    5. ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Long HK, et al. Biochem Soc Trans, 2013 Jun. PMID 23697932, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CXXC-type zinc finger protein 1
    Names
    CXXC finger 1 (PHD domain)
    cpG-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079698.1 → NP_001073166.1  CXXC-type zinc finger protein 1

      See identical proteins and their annotated locations for NP_001073166.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128781
      UniProtKB/TrEMBL
      A1A5S2, A6KRE4
      Conserved Domains (3) summary
      pfam02008
      Location:167 → 213
      zf-CXXC; CXXC zinc finger domain
      cd15553
      Location:28 → 73
      PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
      pfam12269
      Location:406 → 640
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      70088407..70093786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096641.2 → XP_038952569.1  CXXC-type zinc finger protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KRE5

    2. XM_006254917.4 → XP_006254979.1  CXXC-type zinc finger protein 1 isoform X3

      UniProtKB/TrEMBL
      A6KRE4
      Related
      ENSRNOP00000020472.5
      Conserved Domains (3) summary
      pfam02008
      Location:167 → 213
      zf-CXXC; CXXC zinc finger domain
      cd15553
      Location:28 → 73
      PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
      pfam12269
      Location:410 → 644
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    3. XM_039096642.2 → XP_038952570.1  CXXC-type zinc finger protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KRE5
    Nucleotide Protein Strain
    Heading Accession and Version

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