Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eef1e1provided by RGD
Official Full Name: eukaryotic translation elongation factor 1 epsilon 1provided by RGD
Primary source: RGD:1311056
See related: Ensembl:ENSRNOG00000066344 AllianceGenome:RGD:1311056
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of apoptotic process; and positive regulation of cellular senescence. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; positive regulation of DNA damage response, signal transduction by p53 class mediator; and positive regulation of apoptotic signaling pathway. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Orthologous to human EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 251.4), Brain (RPKM 203.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (26354247..26364953)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (26148652..26159358)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (26785017..26795723)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of aminoacyl-tRNA synthetase multienzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation elongation factor 1 epsilon-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106106.1 → NP_001099576.1 eukaryotic translation elongation factor 1 epsilon-1

See identical proteins and their annotated locations for NP_001099576.1

Status: PROVISIONAL

Source sequence(s)

CH473977

UniProtKB/TrEMBL

A0A8I6AE61, B2RYN3

Related

ENSRNOP00000092572.1, ENSRNOT00000111273.1

Conserved Domains (1) summary

cd10305
Location:65 → 165

GST_C_AIMP3; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 3