Galk1 galactokinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Galk1provided by RGD
Official Full Name: galactokinase 1provided by RGD
Primary source: RGD:1305375
See related: Ensembl:ENSRNOG00000006359 AllianceGenome:RGD:1305375
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glk; Galk
Summary: Enables ATP binding activity; galactokinase activity; and galactose binding activity. Involved in carbohydrate phosphorylation and galactose metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in cataract and galactokinase deficiency. Orthologous to human GALK1 (galactokinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 439.4), Kidney (RPKM 215.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (101742067..101746244, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (101243146..101247323, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (104560322..104564499, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125895 (e-PCR)
- UniSTS:162621

RH94625 (e-PCR)
- UniSTS:119873

RH133409 (e-PCR)
- UniSTS:216692

RH130868 (e-PCR)
- UniSTS:214152

Galk1 (e-PCR), detects polymorphism
- UniSTS:546783

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables galactokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactokinase activity	ISO Inferred from Sequence Orthology more info
enables galactose binding	IDA Inferred from Direct Assay more info	PubMed
enables galactose binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within galactitol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in galactose catabolic process via UDP-galactose	ISO Inferred from Sequence Orthology more info
involved_in galactose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactose metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within galactose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in galactose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycolytic process from galactose	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: galactokinase

NP_001008283.1

EC 2.7.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.