U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TOP2B DNA topoisomerase II beta [ Bos taurus (cattle) ]

    Gene ID: 282097, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TOP2Bprovided by VGNC
    Official Full Name
    DNA topoisomerase II betaprovided by VGNC
    Primary source
    VGNC:VGNC:49158
    See related
    BGD:BT27563; Ensembl:ENSBTAG00000004593
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 27
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (40133486..40196656)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112444632 Neighboring gene N-glycanase 1 Neighboring gene microRNA mir-2401 Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene retinoic acid receptor beta Neighboring gene uncharacterized LOC132344075

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA topoisomerase 2-beta
    Names
    DNA topoisomerase II, beta isozyme
    topoisomerase (DNA) II beta 180kDa
    XP_024842148.1
    XP_024842149.1
    XP_024842151.1
    XP_024842152.1
    XP_024842154.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40133486..40196656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024986386.2 → XP_024842154.1  DNA topoisomerase 2-beta isoform X1

      UniProtKB/TrEMBL
      F1MU48
      Related
      ENSBTAP00000089599.1, ENSBTAT00000115785.1
      Conserved Domains (2) summary
      PTZ00108
      Location:45 → 1468
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1505 → 1604
      DTHCT; DTHCT (NUC029) region

    2. XM_024986381.2 → XP_024842149.1  DNA topoisomerase 2-beta isoform X2

      UniProtKB/TrEMBL
      F1MU48
      Conserved Domains (2) summary
      PTZ00108
      Location:45 → 1468
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1500 → 1599
      DTHCT; DTHCT (NUC029) region

    3. XM_024986380.2 → XP_024842148.1  DNA topoisomerase 2-beta isoform X3

      UniProtKB/TrEMBL
      F1MU48
      Conserved Domains (2) summary
      PTZ00108
      Location:40 → 1463
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1500 → 1599
      DTHCT; DTHCT (NUC029) region

    4. XM_024986383.2 → XP_024842151.1  DNA topoisomerase 2-beta isoform X4

      UniProtKB/TrEMBL
      F1MU48
      Related
      ENSBTAP00000096641.1, ENSBTAT00000103703.1
      Conserved Domains (2) summary
      PTZ00108
      Location:24 → 1447
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1484 → 1583
      DTHCT; DTHCT (NUC029) region

    5. XM_024986384.1 → XP_024842152.1  DNA topoisomerase 2-beta isoform X5

      UniProtKB/TrEMBL
      F1MU48
      Related
      ENSBTAP00000080586.1, ENSBTAT00000092120.1
      Conserved Domains (2) summary
      PTZ00108
      Location:19 → 1442
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1479 → 1578
      DTHCT; DTHCT (NUC029) region
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.