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    PDE1B phosphodiesterase 1B [ Bos taurus (cattle) ]

    Gene ID: 281970, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PDE1Bprovided by VGNC
    Official Full Name
    phosphodiesterase 1Bprovided by VGNC
    Primary source
    VGNC:VGNC:32672
    See related
    BGD:BT15048; Ensembl:ENSBTAG00000004337
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (25515722..25542388, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene glycosylation dependent cell adhesion molecule 1 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 1A Neighboring gene NCK associated protein 1 like Neighboring gene uncharacterized LOC112446662

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence comparison of the 63-, 61-, and 59-kDa calmodulin-dependent cyclic nucleotide phosphodiesterases. Novack JP, et al. Biochemistry, 1991 Aug 13. PMID 1651112
    2. Molecular cloning of cDNA encoding a "63"-kDa calmodulin-stimulated phosphodiesterase from bovine brain. Bentley JK, et al. J Biol Chem, 1992 Sep 15. PMID 1326531
    3. Genetic association of phosphodiesterase 1B (PDE1B) with carcass traits in Korean cattle. Shin S, et al. Mol Biol Rep, 2012 Apr. PMID 21960012
    4. Dictyostelium calmodulin: affinity isolation and characterization. Jamieson GA Jr, et al. Arch Biochem Biophys, 1983 Dec. PMID 6667031
    5. Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Yan C, et al. Proc Natl Acad Sci U S A, 1995 Oct 10. PMID 7568196, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PDE1B gene is a candidate gene for carcass traits of beef cattle.
      Title: Genetic association of phosphodiesterase 1B (PDE1B) with carcass traits in Korean cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139720

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
    Names
    63 kDa Cam-PDE
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
    cam-PDE 1B
    phosphodiesterase 1B, calmodulin-dependent
    NP_776840.1
    XP_005206149.1
    XP_005206154.1
    XP_005206157.1
    XP_010803122.1
    XP_024847132.1
    XP_024847133.1
    XP_059742092.1
    XP_059742093.1
    XP_059742094.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174415.2 → NP_776840.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

      See identical proteins and their annotated locations for NP_776840.1

      Status: PROVISIONAL

      Source sequence(s)
      M94867
      UniProtKB/Swiss-Prot
      Q01061
      Conserved Domains (2) summary
      pfam00233
      Location:220 → 440
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:80 → 135
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25515722..25542388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005206100.5 → XP_005206157.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1

      See identical proteins and their annotated locations for XP_005206157.1

      UniProtKB/TrEMBL
      Q0VCW5
      Related
      ENSBTAP00000091843.1, ENSBTAT00000094263.1
      Conserved Domains (2) summary
      pfam00233
      Location:221 → 441
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:80 → 136
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. XM_024991364.2 → XP_024847132.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X4

      Related
      ENSBTAP00000099977.1, ENSBTAT00000089693.1
      Conserved Domains (2) summary
      pfam00233
      Location:181 → 398
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:40 → 96
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. XM_059886109.1 → XP_059742092.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2

      UniProtKB/TrEMBL
      A0A452DHX1

    4. XM_059886110.1 → XP_059742093.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X3

      Related
      ENSBTAP00000099417.1, ENSBTAT00000125550.1

    5. XM_005206092.5 → XP_005206149.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2

      See identical proteins and their annotated locations for XP_005206149.1

      UniProtKB/TrEMBL
      A0A452DHX1
      Related
      ENSBTAP00000085978.1, ENSBTAT00000095844.1
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 422
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    6. XM_010804820.4 → XP_010803122.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X4

      See identical proteins and their annotated locations for XP_010803122.1

      Conserved Domains (2) summary
      pfam00233
      Location:181 → 398
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:40 → 96
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    7. XM_005206097.5 → XP_005206154.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X3

      See identical proteins and their annotated locations for XP_005206154.1

      Related
      ENSBTAP00000086930.1, ENSBTAT00000093162.1
      Conserved Domains (2) summary
      pfam00233
      Location:199 → 416
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:58 → 114
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    8. XM_024991365.2 → XP_024847133.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X5

      Conserved Domains (1) summary
      pfam00233
      Location:18 → 235
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    9. XM_059886111.1 → XP_059742094.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X5

    RNA

    1. XR_009494386.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01061.1 GenPept UniProtKB/Swiss-Prot:Q01061

    Gene LinkOut

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