id2a inhibitor of DNA binding 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: id2aprovided by ZNC
Official Full Name: inhibitor of DNA binding 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020910-1
See related: Ensembl:ENSDARG00000055283 AllianceGenome:ZFIN:ZDB-GENE-020910-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: id2; cb321; wu:fa04e03
Summary: Predicted to enable protein dimerization activity. Involved in BMP signaling pathway. Acts upstream of or within several processes, including mitotic intra-S DNA damage checkpoint signaling; regulation of Notch signaling pathway; and regulation of cell proliferation involved in compound eye morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; immature eye; mesoderm; and neural crest. Orthologous to human ID2 (inhibitor of DNA binding 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (34805939..34808165)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (34857993..34860219)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interplay of Zeb2a, Id2a and Batf3 regulates microglia and dendritic cell development in the zebrafish brain.
Title: Interplay of Zeb2a, Id2a and Batf3 regulates microglia and dendritic cell development in the zebrafish brain.
Bone morphogenetic protein signaling regulates biliary epithelial cell proliferation through id2a.
Title: Bone morphogenetic protein signaling governs biliary-driven liver regeneration in zebrafish through tbx2b and id2a.
role of Id2a as an important regulator of hepatic outgrowth via modulation of hepatoblast proliferation and survival during liver development
Title: Id2a is required for hepatic outgrowth during liver development in zebrafish.
the integral role played by Id2a in the gene regulatory network governing the transition from retinoblast proliferation to terminal differentiation during vertebrate retinogenesis.
Title: Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis.
the ventral migration of Cranial neural crest cells (CNCCs) away from a source of Bmps in the dorsal ectoderm promotes ectomesenchyme development by relieving Id2a-dependent repression of Twist1 function.
Title: Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest.
Mosaic analyses reveal that Id2a function in facilitating both cell cycle progression and neuronal differentiation in the retina is non-cell-autonomous, suggesting that Id2a functions upstream of the extrinsic pathways that regulate retinogenesis.
Title: Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics.
id2 is expressed in the tegmentum; midbrain-hindbrain boundary; cerebellum; rhombomeres 2,3,4,6; notochord; and corpuscles of Stannius, and is repressed in mind bomb mutants, suggesting a role of Notch upstream of Id2.
Title: Zebrafish id2 developmental expression pattern contains evolutionary conserved and species-specific characteristics.

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General gene information

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Markers

AA497329 (e-PCR)
- UniSTS:206931

fd12g10.x1 (e-PCR)
- UniSTS:204137

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell dedifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of hepatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell proliferation involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-2a

Names: inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201291.1 → NP_958448.1 DNA-binding protein inhibitor ID-2a

See identical proteins and their annotated locations for NP_958448.1

Status: PROVISIONAL

Source sequence(s)

BC056303

UniProtKB/TrEMBL

F6PFI4, Q0H602, Q7SZQ2

Related

ENSDARP00000072092.3, ENSDART00000077626.4

Conserved Domains (1) summary

cd00083
Location:42 → 83

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...