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    Mxi1 MAX interactor 1, dimerization protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25701, updated on 11-Apr-2024

    Summary

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    Symbol
    Mxi1provided by RGD
    Full Name
    MAX interactor 1, dimerization proteinprovided by RGD
    Primary source
    RGD:3128
    See related
    Ensembl:ENSRNOG00000034078 AllianceGenome:RGD:3128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MXI-WR
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Used to study breast adenocarcinoma and esophageal cancer. Human ortholog(s) of this gene implicated in neurofibrosarcoma and prostate cancer. Orthologous to human MXI1 (MAX interactor 1, dimerization protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 214.1), Muscle (RPKM 205.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mxi1 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (262329274..262389037)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (252323915..252383682)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (274030748..274090071)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484836 Neighboring gene uncharacterized LOC134484110 Neighboring gene uncharacterized LOC108349710 Neighboring gene survival motor neuron domain containing 1 Neighboring gene uncharacterized LOC103691375 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mxi1 is a potential cellular target of carcinogens and frequently mutated in experimental rat tumors and tumor cell lines. Wang DY, et al. Pathol Int, 2000 May. PMID 10849326
    2. The influence of H-2 gene products on cell-mediated and humoral immune responses. von Boehmer H, et al. Cold Spring Harb Symp Quant Biol, 1977. PMID 70302
    3. Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression. Manni I, et al. Br J Cancer, 2002 Feb 1. PMID 11875718, Free PMC Article
    4. Dynamic in vivo interactions among Myc network members. Yin X, et al. Oncogene, 2001 Aug 2. PMID 11498788
    5. Mxi1 mutations in human neurofibrosarcomas. Li XJ, et al. Jpn J Cancer Res, 1999 Jul. PMID 10470286, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    max-interacting protein 1
    Names
    Max interacting protein 1
    Max interactor 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013160.2 → NP_037292.2  max-interacting protein 1

      See identical proteins and their annotated locations for NP_037292.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081824
      UniProtKB/Swiss-Prot
      O09015
      UniProtKB/TrEMBL
      K3W4V2, Q642D1
      Related
      ENSRNOP00000040770.3, ENSRNOT00000042822.5
      Conserved Domains (1) summary
      cd18930
      Location:68 → 147
      bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      262329274..262389037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231604.1 → XP_006231666.1  max-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006231666.1

      UniProtKB/TrEMBL
      A0A096MJ60, A6JHU5
      Related
      ENSRNOP00000068001.1, ENSRNOT00000076387.3
      Conserved Domains (1) summary
      smart00353
      Location:140 → 192
      HLH; helix loop helix domain

    2. XM_006231606.2 → XP_006231668.1  max-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006231668.1

      UniProtKB/Swiss-Prot
      O09015
      UniProtKB/TrEMBL
      A6JHU9
      Related
      ENSRNOP00000067990.2
      Conserved Domains (1) summary
      cd18930
      Location:32 → 111
      bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09015.1 GenPept UniProtKB/Swiss-Prot:O09015

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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