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    spt16 FACT complex component Spt16 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541355, updated on 11-Apr-2024

    Summary

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    Gene symbol
    spt16
    Gene description
    FACT complex component Spt16
    Primary source
    PomBase:SPBP8B7.19
    Locus tag
    SPBP8B7.19
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3671316..3674622)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene TENA/THI family protein Neighboring gene miscRNA Neighboring gene putative RNA methyltransferase Nop2 Neighboring gene ubiquitin hydrolase Ubp3 Neighboring gene putative HDEL receptor Neighboring gene putative ubiquitin-protein ligase E3 Neighboring gene autophagy-associated protein Atg8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Murawska M, et al. Mol Cell, 2020 Feb 6. PMID 31837996, Free PMC Article
    2. The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi. Lejeune E, et al. Curr Biol, 2007 Jul 17. PMID 17614284, Free PMC Article
    3. The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states. Murawska M, et al. Cell Rep, 2021 Nov 2. PMID 34731638, Free PMC Article
    4. Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading. Dong Q, et al. Mol Cell, 2016 Oct 6. PMID 27666591, Free PMC Article
    5. Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation. Gal C, et al. EMBO Rep, 2016 Jan. PMID 26582768, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to H2A-H2B histone complex chaperone activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables H2A-H2B histone complex chaperone activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables H2A-H2B histone complex chaperone activity IC
    Inferred by Curator
    more info
    		  
    enables histone chaperone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IC
    Inferred by Curator
    more info
    		  
    involved_in chromatin organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in constitutive heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of FACT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FACT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of euchromatin EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FACT complex component Spt16

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3671316..3674622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022447.2 → NP_596526.1  FACT complex component Spt16 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596526.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94267
      Conserved Domains (5) summary
      COG5406
      Location:1 → 1018
      COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]
      cd01091
      Location:181 → 427
      CDC68-like; Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.
      pfam08512
      Location:815 → 896
      Rtt106; Histone chaperone Rttp106-like
      pfam08644
      Location:545 → 690
      SPT16; FACT complex subunit (SPT16/CDC68)
      pfam14826
      Location:6 → 168
      FACT-Spt16_Nlob; FACT complex subunit SPT16 N-terminal lobe domain
    Nucleotide Protein
    Heading Accession and Version

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